Antitumor and immunostimulating effects of Anoectochilus formosanus Hayata

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
C-C TsengK-T Cheng

Abstract

The water extract of Anoectochilus formosanus Hayata showed a potent tumor inhibitory activity in BALB/c mice after subcutaneous transplantation of CT-26 murine colon cancer cells. The tumor-inhibition ratios of mice pre-administered with A. formosanus for 2 days before tumor transplantation, and treated further for 12 consecutive days, were 55.4% and 58.9% at the oral dose of 50 and 10 mg/mouse per day, respectively. Even for the tumor-bearing mice, after oral administration of the water extract of A. formosanus for 12 consecutive days, the tumor inhibition ratios were still 23.8% and 40.5% at doses of 50 and 10 mg/mouse, respectively. Because the low-concentration water extract of A. formosanus does not show direct cytotoxicity in CT-26 tumor cells, we observed further that oral administration of the water extract of A. formosanus may activate murine immune responses, such as stimulating the proliferation of lymphoid tissues and activating the phagocytosis of peritoneal macrophages against Staphylococcus aureus. This study suggests that the antitumor activity of A. formosanus may be associated with its potent immunostimulating effect. It is worth further analyzing the immunomodulating component purified from A. formosanus, an...Continue Reading

References

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Citations

Dec 10, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li-Chan YangWen-Chuan Lin
Jan 23, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C-C HsiehW-C Lin
Nov 26, 2013·Molecular Ecology Resources·Hye Min KimChong-Wook Park
Jun 10, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kur-Ta ChengShu-Hui Juan
May 18, 2017·Genome Génome / Conseil National De Recherches Canada·Iffat ParveenShashi B Babbar
Aug 4, 2018·Current Medical Science·Chang-Xing QiYong-Hui Zhang
May 8, 2020·Oxidative Medicine and Cellular Longevity·Paola AielloWesam Kooti
Jul 3, 2021·Journal of Ethnopharmacology·Myong Hak RiXuejun Jin
Aug 14, 2021·Journal of Toxicology and Environmental Health. Part a·Doan Chinh ChungNghia Son Hoang

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