Sep 1, 1975

Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships

Cancer Chemotherapy Reports. Part 1
K OostuT Kishi

Abstract

The antitumor and immunosuppressive activities of the lankacidin-group antibiotics were studied in mice. Seventeen of 29 newly prepared lankacidin-group antibiotics, including 14-derivatives of lankacidin C, lankacidinol, isolankacidinol, and lankacidinol 14-acetate, possessed considerable antitumor activity against ascites 6C3HED/OG lymphosarcoma. Comparative studies on the antitumor activity of lankacidin C and eight of its derivatives against L1210 leukemia and solid 6C3HED/OG lymphosarcoma demonstrated that replacement of the hydroxyl group at position 8 or 14 of lankacidin C by an acyloxy group potentiated antitumor activity. However, these modifications of lankacidin C resulted in reduction of the immunosuppressive activity.

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Mentioned in this Paper

Lymphoma, Non-Hodgkin
Spleen
Structure-Activity Relationship
Dall Sheep
Graft Vs Host Reaction
Lactones
Mice, Inbred DBA
Antibody Formation
Mice, Inbred C3H
Sarcoma, Jensen

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