PMID: 8958182Jan 1, 1996Paper

Antitumor diarylsulfonylureas: novel agents with unfulfilled promise

Investigational New Drugs
P J Houghton, J A Houghton

Abstract

Diarylsulfonylureas represent a class of antitumor agent with significant therapeutic efficacy against rodent and human models of cancer. Despite the exciting preclinical activity of sulofenur, the prototypic agent, clinical activity was poor. Here we review the activity of sulofenur and a second generation diarylsulfonylurea, LY295501 N-[5-(2, 3-dihydrobenzofuryl) sulfonyl]-N'-(3,4-dichlorophenyl)urea, against colon tumor xenografts, and some of the cellular pharmacology of this class of antitumor agents.

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Citations

Aug 5, 2010·Apoptosis : an International Journal on Programmed Cell Death·Dong-Myung KimShinWu Jeong
Jul 14, 1999·Cancer Letters·E Y MoonS J Yoon
Oct 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A MastrolorenzoC T Supuran
Mar 24, 2010·The Mount Sinai Journal of Medicine, New York·Dara CannataDerek LeRoith
Nov 18, 2004·Bioorganic & Medicinal Chemistry Letters·Semi KimSang-Hun Jung
Nov 27, 2009·European Journal of Medicinal Chemistry·Magda A El-SherbenyMusa A Ahmed
May 1, 2017·Chemical Biology & Drug Design·Vahid Shafiei-IrannejadNosratollah Zarghami
Dec 1, 2012·Asian-Australasian Journal of Animal Sciences·Eun Sook Ji, Kyu-Hyun Park
Sep 18, 2013·The Oncologist·Giulia PaselloAdolfo Favaretto
Feb 21, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiangming GuanJill Pellegrini
Feb 6, 2018·Journal of Medicinal Chemistry·Nicholas A Meanwell

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