PMID: 16531714Mar 15, 2006Paper

Antitumor effect of docetaxel against human esophagus tumor cell lines and tumor xenografts in nude mice

Gan to kagaku ryoho. Cancer & chemotherapy
Shuji ShakutoMasahide Fujita

Abstract

The antitumor effect of docetaxel against cultured human esophagus tumor cell lines and tumor xenografts in nude mice was investigated. In the in vitro study, docetaxel showed concentration-dependent inhibition of the growth of 4 tumor cell lines having different degrees of differentiation (T. T, TE-5, TE-9 and TE-15) with IC(50) values ranging from 0.84 to 1.68 ng/ml when exposed for 72 h. These values represent ca. 1/2,700-1/1,400 of the mean maximum plasma concentration of 2.27 microg/ml attained in the clinical setting. In addition, the activity was found to be ca. two-fold stronger than that of paclitaxel, and much more potent than fluorouracil and cisplatin. The in vivo antitumor effect of docetaxel was also investigated against xenografts of human esophagus squamous cell carcinoma H-190 (highly differentiated) and H-204 (moderately differentiated) in nude mice. Docetaxel at its Maximum Tolerated Dose (MTD) and the lower dose (4.5, 6.7 mg/kg/dose, q 4 d x 3, iv) showed a significant growth inhibition of ca. 100% against H-190 tumor, resulting in the tumor shrinkage. Paclitaxel (6.7, 10 mg/kg/dose, q 4 d x 3, iv) showed a tumor-shrinking effect similar to that seen with docetaxel. In the H-204 xenograft model, docetaxel (4...Continue Reading

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.