Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

World Journal of Gastrointestinal Oncology
Roberta GazianoFrancesca Pica

Abstract

Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strate...Continue Reading

Citations

Sep 14, 2016·International Journal of Molecular Sciences·Andrew CroakerLei Liu
Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea BalažováPavel Mučaji
Jun 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroshi Ogawara
Nov 7, 2018·Anti-cancer Agents in Medicinal Chemistry·Rohit DuttAnil K Madan
Jun 22, 2017·Future Medicinal Chemistry·Iman W AchkarShahab Uddin
Mar 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea BalažováPavel Mučaji
Jul 20, 2020·Pflügers Archiv : European journal of physiology·Gaohua ZhangXuan Zhang
Apr 5, 2018·Frontiers in Molecular Biosciences·Nitika Singh, Bechan Sharma
Mar 15, 2018·Frontiers in Pharmacology·Mohamed E M SaeedHeba Abdel-Aziz
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta Hałas-WiśniewskaAlina Grzanka
Nov 1, 2020·International Journal of Dermatology·Lauren Fravor, Amor Khachemoune
Aug 14, 2019·Cell Chemical Biology·Chenxiao JiangYongjun Dang
Jan 16, 2021·Cancer Management and Research·Marta Hałas-WiśniewskaAlina Grzanka
Jun 4, 2021·Toxicon : Official Journal of the International Society on Toxinology·Mohammad A AlfhiliAhmed B Basudan
Jul 22, 2021·Cancer Cell International·Yanming LuoHaiyang Yu
Dec 5, 2017·ACS Omega·Yit-Lai ChowFumihiko Sato

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