PMID: 18199983Jan 18, 2008Paper

Antitumor efficacy of autovaccines prepared from chemoresistant tumor cells with the use of lectin OF B. subtilis B-7025

Experimental Oncology
G PotebnyaV Chekhun

Abstract

To study whether immunogenecity of tumor cells may be altered upon the development of cytostatic drug resistance and what is the efficacy of vaccines prepared from such tumor cells. Using immunological methods, the influence of vaccines prepared from Lewis lung carcinoma (LLC) cells, sensitive or resistant to cisplatin, with the use of cytotoxic lectins of B. subtilis B-7025 on the course of tumor development and the main effector reactions of antitumor resistance has been studied. The vaccine prepared from the cells of chemoresistant LLC and lectines of B. subtilis B-7025 possesses antitumor activity, what is evidenced by the indexes of tumor growth inhibition and increased activity of effector cells of antitumor immunity. The antitumor action of vaccines prepared with the use of chemoresistant tumor cells is differing is more pronounced, than in the case of chemosensitive variant.

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