Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin

H NishinoA Iwashima


Glycyrrhetic acid inhibited the action of tumor promoter in vitro and in vivo. Glycyrrhetic acid inhibited the increased phospholipid metabolism of cultured cells induced by tumor promoters, 12-O-tetradecanoylphorbol-13-acetate or teleocidin, and it markedly suppressed the promoting effect of teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.


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Related Concepts

Teleocidin B-4
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