PMID: 16518058Mar 7, 2006Paper

Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Hiroshi HaradaMasahiro Hiraoka

Abstract

The genomic information obtained through the human genome project has been accelerating the analysis of the functions of various disease relevant genes. The high molecular weight biomolecules, including oligonucleotides, antisense nucleotides, small interference RNA and peptides, as well as genes (cDNA) and proteins, are becoming increasingly important for the development of molecular therapies. However, the potential of such information-rich macromolecules for therapeutic use has been limited by the poor permeability across the lipid bilayer of the cellular plasma membrane. Over the past decade, a unique activity of oligopeptides, known as protein transduction domains (PTDs) or cell penetrating peptides (CPPs), has made it possible to transduce biologically active macromolecules into living cells in vitro by conjugating a PTD to the desired macromolecule. Furthermore, this activity has also enabled the systemic delivery of bioactive macromolecules to all tissues in living animals. However, we are now confronted with the next difficulty delivering the macromolecules specifically to the therapeutic targets in vivo. In this review, we focus on the application of PTD to develop antitumor macromolecules and introduce several repres...Continue Reading

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P LipponenK Syrjänen
May 1, 1994·Nature Genetics·J R GnarraF M Duh
Aug 1, 1994·The Journal of Pathology·P K Lipponen, S Aaltomaa
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·D PragerS Melmed
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·S FawellJ Barsoum
Jul 1, 1993·Genes & Development·X WuA J Levine
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·C M TroyM L Shelanski
Jul 26, 1996·The Journal of Biological Chemistry·D DerossiA Prochiantz
Sep 1, 1996·Molecular and Cellular Biology·J A ForsytheG L Semenza
Jul 17, 1997·Nature·Q L DeverauxJ C Reed
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A EzhevskyS F Dowdy
May 22, 1998·Breast Cancer Research and Treatment·P HohenbergerP M Schlag
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·T KamijoC J Sherr
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Mar 31, 1999·Trends in Biochemical Sciences·C V Dang, G L Semenza
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y N ChenW G Kaelin
Feb 26, 2000·Carcinogenesis·S W Lowe, A W Lin
Mar 25, 2000·Endocrine-related Cancer·P Lipponen
May 16, 2000·Biochemical Pharmacology·A Astriab-FisherR L Juliano
Oct 12, 2000·The Journal of Biological Chemistry·M TyagiM Giacca
Dec 1, 2000·Nature·B VogelsteinA J Levine
Feb 22, 2001·Journal of the National Cancer Institute·R BosE van der Wall
May 11, 2001·The Journal of Biological Chemistry·A EguchiM Nakanishi
Jun 14, 2001·Methods : a Companion to Methods in Enzymology·M Becker-HapakS F Dowdy
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·V P TorchilinT S Levchenko
Mar 22, 2002·Nature Reviews. Cancer·F McCormick
Aug 3, 2002·Nature Reviews. Cancer·Karen H Vousden, Xin Lu
Sep 3, 2002·Cancer Cell·Charles J Sherr, Frank McCormick

❮ Previous
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Citations

Apr 10, 2012·Bulletin of Experimental Biology and Medicine·E V KhokhlovaA N Shkoporov
May 6, 2009·Expert Opinion on Drug Delivery·Matan Rapoport, Haya Lorberboum-Galski
Aug 13, 2011·Expert Opinion on Investigational Drugs·Alexandre PereiraIrina Kerkis
Feb 9, 2010·Trends in Molecular Medicine·Stefan Grimm, Mathieu Noteborn
Aug 17, 2010·Drug Development Research·Feng Tao, Roger A Johns
Jul 27, 2010·Biochemical and Biophysical Research Communications·Yuriko SaitoTsuneo Saga
Oct 23, 2013·Future Oncology·Sarah Declerck, Johan Vansteenkiste
Sep 26, 2006·Drug Discovery Today·Mariko Morishita, Nicholas A Peppas
Oct 8, 2008·Journal of Biochemistry·Naoya KurataAkihiko Kondo
Jan 15, 2013·International Journal of Oncology·Jikai YinJianguo Lu
Aug 8, 2019·ACS Applied Materials & Interfaces·Wei Qi LimYanli Zhao

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