Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and Ancistrocladus abbreviatus (Ancistrocladaceae)

Phytochemistry
Gerhard BringmannManik Chatterjee

Abstract

From the methanolic extracts of solid callus cultures from two species of the closely related palaeotropical plant families Dioncophyllaceae and Ancistrocladaceae seven new natural naphthoquinones were isolated, dioncoquinones A (4) and B (5) from Triphyophyllum peltatum, and ancistroquinones B (6), C (7), D (9), E (10), and F (12) from Ancistrocladus abbreviatus. Their structures were elucidated by spectroscopic, chemical, and computational methods. Furthermore, the already known naphthoquinones plumbagin (2), droserone (3), malvone A (8), and nepenthone A (11) were found in the extract of A. abbreviatus. Dioncoquinones A (4) and B (5) showed good - and specific - activity against Leishmania major, while they were not active against other protozoic parasites. Moreover, treatment with 4 and 5 strongly induced apoptosis in human tumor cells derived from two different B cell malignancies, B cell lymphoma and multiple myeloma, without any significant toxicity towards normal peripheral mononuclear blood cells.

References

Jan 1, 1969·Chemische Berichte·H BrockmannA Zeeck
May 15, 1998·Planta medica·K LikhitwitayawuidJ Krungkrai
Sep 18, 2001·Journal of Experimental Botany·G Bringmann, D Feineis
Feb 6, 2002·Chembiochem : a European Journal of Chemical Biology·R Thomas
Mar 7, 2003·Phytochemistry·Gerhard BringmannLaurent Aké Assi
Sep 26, 2006·Phytochemistry·Olga VeshkurovaRobert D Stipanovic

❮ Previous
Next ❯

Citations

Aug 21, 2013·Journal of Asian Natural Products Research·Shi-Wei SunTian-Jiao Zhu
Mar 20, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Negera AbdissaMáté Erdélyi
Sep 26, 2014·Chemical Reviews·Hidayat HussainSimon Gibbons
Oct 25, 2011·European Journal of Medicinal Chemistry·Gerhard BringmannManik Chatterjee
Oct 13, 2012·Medicinal Research Reviews·Subhash PadhyeFazlul H Sarkar
Sep 22, 2015·Fitoterapia·Sabrin R M Ibrahim, Gamal A Mohamed
Dec 21, 2013·Bioorganic & Medicinal Chemistry·Nisha SinghVinod K Tiwari
Jul 13, 2018·Chemistry & Biodiversity·Foroogh RezaeiGholamreza Hatam
Jan 7, 2020·Chemical & Pharmaceutical Bulletin·Dmitry Aminin, Sergey Polonik
Aug 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuri E SabutskiSergey G Polonik
Jun 12, 2020·European Journal of Medicinal Chemistry·Ana R GomesFernanda M F Roleira
Jun 3, 2021·Cancers·Karin Jöhrer, Serhat Sezai Ҫiҫek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis