Abstract
The effects of a new titanocene compound with an ansa ligand in the cyclopentadienyl rings, the 1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride (TITANOCENE X), on the growth and differentiation of granulocyte-macrophage progenitor cells [colony-forming unit-granulocyte-macrophage (CFU-GM)] and Natural killer (NK) cell activity in Ehrlich's ascites tumour (EAT)-bearing mice were studied. Myelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with TITANOCENE X (2.5-50 mg/kg/day) produced an increase in myelopoiesis, in a dose-dependent manner, and reduced spleen colony formation. In addition, the treatment of EAT-bearing mice with 3 doses of 20 or 50 mg/kg TITANOCENE X restored to normal values the reduced Natural killer cell function observed during tumour growth. In parallel, TITANOCENE X prolonged, in a dose-dependent manner, the survival of mice inoculated with Ehrlich's ascites tumour. The highest dose of 50 mg/kg prolonged in 50% the survival time of EAT-bearing mice, compared to non-treated tumour-bearing controls. In comparison with previous results from our laboratory addressing the effects of titanoce...Continue Reading
References
Jan 1, 1992·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·L Balducci, C L Hardy
Aug 15, 1989·International Journal of Cancer. Journal International Du Cancer·J L SubizaE G De La Concha
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·P Köpf-Maier
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·P Köpf-Maier
Jul 1, 1985·Cellular Immunology·P K LalaR S Parhar
Apr 26, 1969·Nature·B RosenbergV H Mansour
Jan 1, 1982·Oncology·A PessinaP Mocarelli
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·P Köpf-MaierE Liss
Dec 5, 1998·International Journal of Immunopharmacology·M C ValadaresM L Queiroz
Jun 26, 1999·General Pharmacology·R Bakhtiar, E I Ochiai
Jan 21, 2000·Experimental Hematology·J Ruiz de MoralesJ L Subiza
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S KimW M Yokoyama
Oct 18, 2000·Current Medicinal Chemistry·M M Harding, G Mokdsi
Mar 10, 2001·Journal of Inorganic Biochemistry·G Mokdsi, M M Harding
May 2, 2001·Journal of Inorganic Biochemistry·J R BoylesN Jain
Dec 26, 2001·Chemical Reviews·E Wong, C M Giandomenico
Apr 9, 2002·European Journal of Pharmacology·Marize C Valadares, Mary L S Queiroz
Aug 2, 2003·European Journal of Pharmacology·Marize C ValadaresMary L S Queiroz
Feb 3, 2004·Mini Reviews in Medicinal Chemistry·Francesco Caruso, Miriam Rossi
Apr 24, 2004·Analytical and Bioanalytical Chemistry·José L VeraEnrique Meléndez
Oct 22, 2004·European Journal of Pharmacology·Marize C ValadaresMary L S Queiroz
Nov 16, 2004·Journal of Inorganic Biochemistry·Matthias TackeNigel Sweeney
Jan 22, 2005·Immunopharmacology and Immunotoxicology·Mary L S QueirozG C Dieamant
Citations
Jun 19, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Idainés FelicianoEnrique Meléndez
May 23, 2007·Investigational New Drugs·Thomas HickeyMatthias Tacke
Nov 9, 2010·Nutrition and Cancer·Aline Lisie RamosMary L S Queiroz
Feb 1, 2007·Anti-cancer Drugs·Philipp BeckhoveMatthias Tacke
Feb 1, 2007·Anti-cancer Drugs·Olaf OberschmidtMatthias Tacke
Dec 14, 2011·Clinical and Experimental Pharmacology & Physiology·C O TorelloM L S Queiroz
Feb 16, 2008·Metal-based Drugs·Megan HoganMatthias Tacke
Aug 1, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Clara PampillónMatthias Tacke
Jun 15, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Li Ming GaoEnrique Meléndez
Feb 22, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ramón HernándezEnrique Meléndez
Mar 18, 2008·Journal of Ethnopharmacology·Mary L S QueirozWalter R Accorci
Nov 6, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Holger WeberMatthias Tacke
Apr 7, 2007·European Journal of Medicinal Chemistry·Clara PampillónMatthias Tacke
Oct 10, 2007·British Journal of Cancer·J H BannonM M Mc Gee
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Olivia R AllenPatrick C McGowan
Jan 11, 2008·ChemMedChem·James ClaffeyMatthias Tacke
May 24, 2008·Chemical Society Reviews·Katja Strohfeldt, Matthias Tacke
Oct 2, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Olivia R AllenPatrick C McGowan
Jan 7, 2011·Metallomics : Integrated Biometal Science·Susan W SarsamKimberly A Watson