Antitumour activity of [1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride in xenografted Ehrlich's ascites tumour

European Journal of Pharmacology
Marize C ValadaresMary L S Queiroz

Abstract

The effects of a new titanocene compound with an ansa ligand in the cyclopentadienyl rings, the 1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride (TITANOCENE X), on the growth and differentiation of granulocyte-macrophage progenitor cells [colony-forming unit-granulocyte-macrophage (CFU-GM)] and Natural killer (NK) cell activity in Ehrlich's ascites tumour (EAT)-bearing mice were studied. Myelosuppression concomitant with increased numbers of spleen CFU-GM was observed in tumour-bearing mice. Treatment of these animals with TITANOCENE X (2.5-50 mg/kg/day) produced an increase in myelopoiesis, in a dose-dependent manner, and reduced spleen colony formation. In addition, the treatment of EAT-bearing mice with 3 doses of 20 or 50 mg/kg TITANOCENE X restored to normal values the reduced Natural killer cell function observed during tumour growth. In parallel, TITANOCENE X prolonged, in a dose-dependent manner, the survival of mice inoculated with Ehrlich's ascites tumour. The highest dose of 50 mg/kg prolonged in 50% the survival time of EAT-bearing mice, compared to non-treated tumour-bearing controls. In comparison with previous results from our laboratory addressing the effects of titanoce...Continue Reading

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Citations

Jun 19, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Idainés FelicianoEnrique Meléndez
Feb 1, 2007·Anti-cancer Drugs·Olaf OberschmidtMatthias Tacke
Dec 14, 2011·Clinical and Experimental Pharmacology & Physiology·C O TorelloM L S Queiroz
Feb 16, 2008·Metal-based Drugs·Megan HoganMatthias Tacke
Aug 1, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Clara PampillónMatthias Tacke
Jun 15, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Li Ming GaoEnrique Meléndez
Feb 22, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ramón HernándezEnrique Meléndez
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Apr 7, 2007·European Journal of Medicinal Chemistry·Clara PampillónMatthias Tacke
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Olivia R AllenPatrick C McGowan
Jan 11, 2008·ChemMedChem·James ClaffeyMatthias Tacke
May 24, 2008·Chemical Society Reviews·Katja Strohfeldt, Matthias Tacke
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Jan 7, 2011·Metallomics : Integrated Biometal Science·Susan W SarsamKimberly A Watson

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