Antitumour activity of cis-diamminedichloroplatinum (II) against human tumour xenografts depends on its area under the curve in nude mice

Journal of Surgical Oncology
N KuriharaM Kitajima

Abstract

A pharmacodynamic analysis of cis-diamminedichloroplatinum(II) (DDP) was conducted using two human gastric cancer xenografts, SC-1-NU and MKN-45, and one human breast cancer xenograft, MX-1, grown serially in BALB/c nu/nu mice. DDP was administered intraperitoneally (i.p.) at a total dose of 5, 10, or 20 mg/kg in a schedule of q7d x 3 or (qd x 5) x 3. DDP was also administered i.p. to BALB/c +/? mice, whose plasma was used for the assay of total and free platinum by the atomic absorption method. A total dose of 20 mg/kg DDP seemed to be the maximum tolerated dose that was effective on MX-1 and SC-1-NU. When the totally administered doses were equivalent, the antitumor effects of the q7d x 3 and (qd x 5) x 3 schedules were similar to each other. The antitumor activity of DDP against MKN-45 was dependent on the total administered dose as well as the area under the curve of free and total platinum in the plasma. Side effects were significantly reduced using a schedule of (qd x 5) x 3 in terms of body and spleen weight loss when a total of 10 or 20 mg of DDP per kg was administered. These results suggest that DDP would be useful when administered using a daily schedule for obtaining the same antitumor activity as that of bolus inje...Continue Reading

References

Nov 1, 1978·Cancer·C JacobsR L Goode
Jun 1, 1990·Japanese Journal of Clinical Oncology·K MiyamotoN Okazaki
Apr 1, 1988·Japanese Journal of Cancer Research : Gann·S WatanabeY Ohno
May 1, 1984·Gan to kagaku ryoho. Cancer & chemotherapy·M Ogawa
May 1, 1984·Annals of Internal Medicine·P J Loehrer, L H Einhorn
Jun 1, 1983·European Journal of Cancer & Clinical Oncology·M BeerF Cavalli
Mar 1, 1983·The Japanese Journal of Surgery·T KanoK Inokuchi

❮ Previous
Next ❯

Citations

Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·A ChahlaviS D Rabkin
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takashi TamuraHiroyuki Yoshino
Jul 19, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xiaolin LiBaorui Liu
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mitsunaga KonishiShingo Fujii
Oct 9, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yutaro KandaRyosuke Kuroda
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Seiji MabuchiMasahide Ohmichi
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Seiji MabuchiJoseph R Testa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.