Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil

Basic & Clinical Pharmacology & Toxicology
Larissa M BomfimDaniel P Bezerra

Abstract

Annona vepretorum Mart. (Annonaceae), popularly known as 'bruteira', has nutritional and medicinal uses. This study investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed with β-cyclodextrin in a microencapsulation. The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus and analysed using GC-MS and GC-FID. In vitro cytotoxicity of the essential oil and some of its major constituents in tumour cell lines from different histotypes was evaluated using the alamar blue assay. Furthermore, the in vivo efficacy of essential oil was demonstrated in mice inoculated with B16-F10 mouse melanoma. The essential oil included bicyclogermacrene (35.71%), spathulenol (18.89%), (E)-β-ocimene (12.46%), α-phellandrene (8.08%), o-cymene (6.24%), germacrene D (3.27%) and α-pinene (2.18%) as major constituents. The essential oil and spathulenol exhibited promising cytotoxicity. In vivo tumour growth was inhibited by the treatment with the essential oil (inhibition of 34.46%). Importantly, microencapsulation of the essential oil increased in vivo tumour growth inhibition (inhibition of 62.66%).

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Citations

Jun 15, 2016·Journal of Natural Products·Emmanoel V CostaAndersson Barison
May 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chi-Ya HuangHui-Ting Chang
Apr 18, 2017·Annals of the New York Academy of Sciences·Rosa TundisMonica R Loizzo
Nov 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emilly J S P de LimaDaniel P Bezerra
Apr 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elaine C D GonçalvesRafael C Dutra
Sep 12, 2020·Nutritional Neuroscience·Elisangela Dos SantosCandida Aparecida Leite Kassuya
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui-Ting ChangShang-Tzen Chang
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Igor A SchepetkinMark T Quinn

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