Antitussive activity of iodo-resiniferatoxin in guinea pigs

Thorax
Marcello TrevisaniPierangelo Geppetti

Abstract

Iodo-resiniferatoxin (I-RTX) has recently been described as an ultra potent antagonist of the transient receptor potential vanilloid-1 (TRPV1). The ability of I-RTX to inhibit cough induced by inhalation of two putative TRPV1 stimulants (capsaicin and citric acid) was tested in non-anaesthetised guinea pigs. Pretreatment with I-RTX either intraperitoneally (0.03-0.3 micromol/kg) or by aerosol (0.1-3 microM) reduced the number of coughs produced by inhalation of citric acid (0.25 M) and capsaicin (30 microM) in a dose dependent manner. Capsazepine (CPZ) also reduced citric acid and capsaicin induced cough, but the activity of I-RTX was 10-100 times more potent than CPZ in all the experimental conditions tested. I-RTX is a novel and potent antitussive drug which inhibits cough mediated by agents possibly acting via TRPV1 activation.

References

Aug 1, 1992·The American Review of Respiratory Disease·B MidgrenC G Persson
Oct 1, 1986·Acta Physiologica Scandinavica·K Forsberg, J A Karlsson
Dec 1, 1994·Trends in Neurosciences·S Bevan, P Geppetti
Aug 1, 1994·American Journal of Respiratory and Critical Care Medicine·F O'ConnellR W Fuller
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·C C ChenJ N Wood
Dec 19, 1998·Respiration Physiology·J G Widdicombe
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·S W HwangU Oh
Oct 27, 2001·British Journal of Clinical Pharmacology·A H MoriceR Thompson
Apr 5, 2002·Trends in Pharmacological Sciences·Martin J GunthorpeJohn B Davis
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Susan M HuangVincenzo Di Marzo
Jun 19, 2002·Neuropharmacology·C D BenhamA D Randall
Sep 3, 2002·The Journal of Physiology·Marian Kollarik, Bradley J Undem
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Jack A KastelikAlyn H Morice

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Citations

Jan 22, 2010·Lung·Pierangelo GeppettiSerena Materazzi
Oct 4, 2011·Lung·Megan S GraceMaria G Belvisi
Apr 28, 2007·Nature Reviews. Drug Discovery·Arpad SzallasiSamer R Eid
Oct 2, 2012·Pharmacological Reviews·Jessica O'NeillAnthony H Dickenson
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Min-Goo LeeMichael J Carr
Sep 5, 2009·American Journal of Respiratory and Critical Care Medicine·Mark A BirrellAlyn H Morice
Jul 1, 2011·Therapeutic Advances in Chronic Disease·Ian D Molyneux, Alyn H Morice
Sep 11, 2012·Multidisciplinary Respiratory Medicine·Mario PolverinoFrancesco De Blasio
Jun 17, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Takanobu ShioyaHiroyuki Watanabe
Jul 6, 2010·Proceedings of the American Thoracic Society·Bret F Bessac, Sven-Eric Jordt
May 28, 2014·Cells·Rafael BritoVickram Ramkumar
Jun 7, 2012·Expert Opinion on Therapeutic Patents·Delia PretiRiccardo Patacchini
Apr 29, 2011·Expert Opinion on Pharmacotherapy·Peter G Gibson, Nicole M Ryan
Jun 8, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ahmed Z El-HashimSaghir Akhtar
Nov 29, 2011·Pharmacology & Therapeutics·E L AndradeJ B Calixto
Nov 16, 2010·Pulmonary Pharmacology & Therapeutics·Megan S Grace, Maria G Belvisi
Feb 4, 2016·The Journal of Pharmacology and Experimental Therapeutics·Emlyn ClayClive Page
Feb 23, 2010·Otolaryngologic Clinics of North America·Brendan J Canning
Mar 3, 2010·Journal of Pharmacological and Toxicological Methods·R VenkatasamyD Spina
Oct 13, 2009·Pharmacology & Therapeutics·Julie Nasra, Maria G Belvisi
Mar 17, 2009·Pulmonary Pharmacology & Therapeutics·Brendan J Canning
Jan 15, 2009·Pulmonary Pharmacology & Therapeutics·John J Adcock
Jun 23, 2015·Pulmonary Pharmacology & Therapeutics·Thomas E Taylor-Clark
Dec 4, 2008·Pulmonary Pharmacology & Therapeutics·Raffaele GattiMarcello Trevisani
Nov 11, 2008·Pulmonary Pharmacology & Therapeutics·Masaya TakemuraDavid A Groneberg
Jun 23, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Q T DinhA Fischer
Oct 23, 2009·British Journal of Pharmacology·E AndrèP Geppetti
Nov 30, 2013·British Journal of Pharmacology·M S GraceM G Belvisi
Mar 27, 2016·Cell Calcium·Thomas E Taylor-Clark
Jun 3, 2006·Respiratory Physiology & Neurobiology·Brendan J CanningStuart B Mazzone
Feb 9, 2006·European Journal of Pharmacology·Pierangelo GeppettiPaola Nicoletti
Jan 13, 2006·Respiratory Physiology & Neurobiology·Peter V Dicpinigaitis
Apr 16, 2016·Pulmonary Pharmacology & Therapeutics·Donatella MutoloFulvia Bongianni
Feb 16, 2005·Expert Opinion on Investigational Drugs·K F Chung
Feb 24, 2015·Current Opinion in Pharmacology·Thomas E Taylor-Clark
Mar 1, 2015·Current Opinion in Pharmacology·Silvia BenemeiPierangelo Geppetti
Mar 12, 2013·Pulmonary Pharmacology & Therapeutics·Megan S GraceMaria G Belvisi
Nov 20, 2012·Drug Discovery Today·Jaymin B MorjariaAlyn H Morice
Mar 26, 2013·Pulmonary Pharmacology & Therapeutics·D Spina, C P Page
Jun 12, 2012·European Journal of Pharmacology·Mariana BrozmanovaMarian Kollarik
Jan 13, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Sara J BonviniMaria G Belvisi
May 24, 2016·PloS One·Eric J ZacconeBradley J Undem

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