PMID: 1180614Aug 1, 1975Paper

Antitussive drugs. I. Cardiopulmonary effects of codeine.

Archives Internationales De Pharmacodynamie Et De Thérapie
A Bianchi, D M Aviado

Abstract

In the anesthetized dog, codeine causes a combination of pulmonary vasoconstriction and systemic vasodilation. Pulmonary blood flow is either increased or decreased, relating to a primary stimulation or depression of myocardial contractility. The overall effect is an elevation in pulmonary arterial pressure largely due to vasoconstriction of the pulmonary blood vessels.

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