PMID: 8940703Oct 1, 1996Paper

Antiulcer properties of shosaiko-to

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
M MatsutaA Yamashita

Abstract

Recently it has been reported that Shosaiko-to (SHO), a traditional Chinese medicine used for treating gastritis and hepatitis, also has been found useful for treating gastric ulcers, although no pharmacological study has yet investigated the precise antiulcer properties of SHO. Herein, the authors report on the results of a rat study in which the effects of SHO on gastric ulcers, acid secretions and potential difference of gastric mucosa (PD) were studied. SHO (100, 250 or 500 mg /kg, p.o.) significantly inhibited the development of ethanol-induced gastric lesions in a dose-dependent manner. SHO (500 mg/kg, p.o.) significantly inhibited the development of aspirin-,indomethacin- or water-immersion-stress induced gastric lesions. Sucralfate (500 mg/kg, p.o.) inhibited both ethanol- and aspirin-induced gastric lesions, and cimetidine (10 mg/kg, p.o.) inhibited aspirin-, indomethacin- or stress-induced gastric lesions. SHO (10, 30 and 100 mg/kg, i.p.) also significantly inhibited pentagastrin- and 2-deoxy-D-glucose (2-DG)-induced gastric acid secretions in a dose-dependent manner, whereas cimetidine (1 mg/kg, i.p.) inhibited a pentagastrin-induced secretion and atropine (0.05 mg/kg, i.p.) inhibited pentagastrin- or 2-DG-induced ac...Continue Reading

Citations

May 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S AmagayaK Terasawa
Feb 24, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·N NishimuraK Iwamoto
Jun 1, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Wei LiuYanwen Liu
May 21, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Min LiQingyong He

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