Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara

Planta medica
A R BritoD S Nunes

Abstract

trans-Dehydrocrotonin (DHC), the major diterpene isolated from Croton cajucara Benth, was assayed for antiulcerogenic activity in four induced gastric ulcer models in the rat. At an oral dose of 100 mg/kg DHC showed a significant antiulcerogenic effect on ulcers induced by hypothermic restraint stress, ethanol, and pylorus ligature. No significant changes in indomethacin-induced gastric lesions or modifications in gastric parameters such as wall mucus, secretion rate, pH, and total acid content were found after DHC treatment. The acute toxicological effects of DHC were assessed in mice. The LD50 values were 876 mg/kg and 47.2 mg/kg for oral and intraperitoneal administrations, respectively. The cytotoxicity of DHC was also studied. A dose-dependent inhibition of cell viability was observed in V-79 fibroblast cell cultures with an IC50 of 240 microM. The high yields of DHC obtained from dried C. cajucara barks as well as its good antiulcerogenic activity and low toxicity support the pharmacological study of this compound as a potential new antiulcerogenic drug.

Citations

Mar 23, 2004·European Journal of Pharmacology·Patricia S MeloMarcela Haun
Mar 3, 2005·European Journal of Pharmacology·Daniel H A CorrêaMarcela Haun
May 27, 2005·Life Sciences·Jaime A RodríguezGuillermo Schmeda-Hirschmann
Jul 23, 2003·European Journal of Pharmacology·Ana Beatriz Albino de AlmeidaAlba R M Souza Brito
May 22, 2002·Journal of Ethnopharmacology·Guillermo Schmeda-HirschmannLuis Astudillo
Mar 18, 2000·Journal of Ethnopharmacology·C A Hiruma-LimaA R Souza Brito
Jul 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jaime A RodríguezGuillermo Schmeda-Hirschmann
May 23, 2003·Antimicrobial Agents and Chemotherapy·Maria do Socorro S do Socorro S RosaAngela Hampshire C S Lopes
Aug 4, 2010·Parasitology Research·Monica C O CamposSolange L de Castro
Apr 16, 2009·Journal of Pharmaceutical Sciences·Lucas FrungilloNelson Durán
Apr 25, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ana Claudia B De PaulaAlba R M Souza Brito
Feb 22, 2005·The Journal of Pharmacy and Pharmacology·Jaime A RodríguezGuillermo Schmeda-Hirschmann
Dec 24, 2005·Phytotherapy Research : PTR·Maribel ReyesJaime A Rodríguez
Aug 5, 2011·Fundamental & Clinical Pharmacology·Mary Tolulope Olaleye, Afolabi Clement Akinmoladun
Apr 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C A Hiruma-LimaA R Souza Brito
Jul 5, 2005·Journal of Ethnopharmacology·Guillermo Schmeda-Hirschmann, Erdem Yesilada
Jun 30, 2005·Journal of Ethnopharmacology·Guillermo Schmeda-HirschmannTania Yáñez
Jun 25, 2005·Vascular Pharmacology·Regilane M SilvaVietla S N Rao
Mar 11, 2015·Fundamental & Clinical Pharmacology·José L R MartinsElson A Costa
Mar 13, 2003·The Journal of Pharmacy and Pharmacology·Dora Maria Grassi-KassisseRegina Célia Spadari-Bratfisch
May 10, 2002·The Journal of Pharmacy and Pharmacology·Luis AstudilloGuillermo Schmeda-Hirschmann
Mar 21, 2002·The Journal of Pharmacy and Pharmacology·Jaime A RodríguezGuillermo Schmeda-Hirschmann
Jul 20, 2016·Natural Product Reports·Rongtao LiKuo-Hsiung Lee
May 27, 1999·The Journal of Pharmacy and Pharmacology·C A Hiruma-LimaA R Souza Brito
Mar 3, 2004·Biological & Pharmaceutical Bulletin·Leônia Maria BatistaAlba Regina Monteiro Souza Brito
Dec 14, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Manoel do Carmo Pereira Soares
Oct 23, 2004·Human & Experimental Toxicology·Jaime A RodríguezAlba R M Souza Brito
Dec 10, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·A R AgnerI M Cólus
May 9, 2002·Biological & Pharmaceutical Bulletin·Clélia Akiko Hiruma-LimaAlba Regina Monteiro Souza Brito
Sep 24, 2004·Canadian Journal of Physiology and Pharmacology·Eliete J B BighettiHelena C F Oliveira
Feb 8, 2002·World Journal of Gastroenterology : WJG·Xin WangDai-Ming Fan
May 29, 2003·Canadian Journal of Physiology and Pharmacology·Nelson DuránMarcela Haun
Mar 4, 2000·The Journal of Pharmacy and Pharmacology·E J BighettiA R Brito
Nov 1, 2008·Environmental Toxicology and Pharmacology·Riaz AhmadAbsar-Ul Hasnain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.