PMID: 11933128Apr 5, 2002Paper

Antiulcerogenic and analgesic effects of the Austroplenckia populnea extracts in mice

Phytotherapy Research : PTR
L N SeitoL C Di Stasi

Abstract

Austroplenckia populnea (Reiss.) Lund. is a Brazilian Cerrado plant belonging to the Celastraceae family. Hexane and methanol extracts of leaves were investigated for their antiulcerogenic (ethanol and indomethacin/bethanecol induced gastric damage) and analgesic (writhing and tail-flick tests) activities in mice. Acute toxic effects also were evaluated. Oral administration of both extracts at a dose of 1000 mg/kg significantly reduced the total area of the lesion, the relative area of lesion and the ulcerative index in ethanol-induced gastric damage, but both extracts were inactive in the indomethacin/bethanecol-induced gastric damage test. A dose dependent effect was determined with the hexane extract in the ethanol-induced lesions test. The hexane and methanol extracts reduced the number of contortions in the writhing test, but both extracts were inactive in the tail-flick immersion test.

Citations

Oct 2, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H S FalcãoJ M Barbosa-Filho
Mar 6, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F AlmeidaC A Tagliati

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