Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria

Journal of Natural Products
Varatharajan SudhaharP Varalakshmi

Abstract

The present study was undertaken to explore the efficiency of the pentacyclic triterpene lupeol (1) and its ester derivative, lupeol linoleate (2), in experimental hyperoxaluria. Hyperoxaluria was induced in male Wistar rats with 0.75% ethylene glycol (EG) in drinking water for 28 days. Hyperoxaluric animals were supplemented orally with 1 and 2 (50 mg/kg body wt/day) throughout the experimental period of 28 days. The renal enzymes were assayed as markers of renal tissue integrity. The redox status and oxalate metabolism in animals under oxalate overloading was also assessed. Microscopic analysis was done to investigate the abnormalities associated with oxalate exposure in renal tissues. Increase in oxidative milieu in hyperoxaluria was evident by increased lipid peroxidation (LPO) and decreased enzymic and nonenzymic antioxidants. Decrease in the activities of renal enzymes exemplified the damage induced by oxalate, which correlated positively with increased LPO and increased oxalate synthesis. Renal microscopic analysis further emphasized the oxalate-induced damage. These abnormal biochemical and histological aberrations were attenuated with test compound treatment, with 2 more effective than 1. From the present study, it can...Continue Reading

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Citations

May 24, 2013·Archives of Pharmacal Research·Weijie LiYeyu Xiao
Dec 2, 2010·Life Sciences·Hifzur Rahman Siddique, Mohammad Saleem
Dec 3, 2014·Journal of Ethnopharmacology·Deepika AggarwalSurinder Kumar Singla
Mar 10, 2016·Pharmaceutical Biology·Dianelena Eugenio-PérezJosé Pedraza-Chaverri
Jun 28, 2017·Chemical Research in Toxicology·Manuel A Ruiz-RodríguezRubén F González-Laredo
Apr 22, 2020·Drug Development Research·Devina LobineMohamad F Mahomoodally
Dec 15, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kai LiuJia Luo
Dec 31, 2020·Plants·Nourhan Hisham ShadyUsama Ramadan Abdelmohsen

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