Antiviral activities of Clinacanthus nutans (Burm.f.) Lindau extract against Cyprinid herpesvirus 3 in koi (Cyprinus carpio koi)

Journal of Fish Diseases
T HaetrakulN Chansue

Abstract

Cyprinid herpesvirus 3 (CyHV-3) or koi herpesvirus (KHV) is a virulent viral infection in common carp and koi. The disease has caused global epizootic and economic loss in fish aquaculture and in the wild. Clinacanthus nutans (Burm. f.) Lindau is a well-known medicinal plant used in Thai traditional medicine. Virucidal effects of the plant extract against human herpes simplex virus have been reported. In this study, C. nutans crude extract was tested for antiviral activities against CyHV-3 in koi carp. Results showed effective antiviral activity against CyHV-3 pre- and post-infection. The 50% lethal concentration (LC50 ) of extract was higher than 5 mg/ml. The 50% effective dose (ED50 ) was 0.99 mg/ml, 0.78 mg/ml, 0.75 mg/ml and 0.71 mg/ml at 1, 2, 3 and 4 hr pre-infection, respectively. The ED50 from post-infection tests was 2.05 mg/ml and 2.34 mg/ml at 0 and 24 hr, respectively. These results demonstrated that crude extract expressed antiviral activity against CyHV-3 and can be applied as a therapeutic agent in common carp and koi aquaculture.

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Citations

Aug 11, 2020·Planta medica·Karin Zitterl-Eglseer, Tatiana Marschik
Dec 1, 2019·BMC Complementary and Alternative Medicine·Nik Mohd Afizan Nik Abd RahmanMohd Azmi Mohd Lila
Jan 15, 2020·Journal of Veterinary Research·Agnieszka TroszokIlgiz Irnazarow
Nov 17, 2020·Frontiers in Veterinary Science·Eva Marie Quijano CardéEsteban Soto
Sep 28, 2021·Chinese Herbal Medicines·Jakaphun JulsrigivalNararat Akarchariya

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