PMID: 6171779Nov 25, 1981Paper

Antiviral activities of hybrids of two major human leukocyte interferons

Nucleic Acids Research
P WeckD V Goeddel

Abstract

Four hybrid human leukocyte interferon (LeIF or IFN-alpha) genes have been constructed by in vitro recombination of LeIF-A (IFN-alpha 2) and LeIF-D (IFN-alpha 1) genes at common restriction endonuclease sites located within their coding regions. These hybrid genes have been expressed in E. coli under trp promoter control. The interferons produced [LeIF-AD (BglII), -AD (PvuII), -DA (BglII), -DA (PvuII)] have antiviral properties distinct from the parental molecules LeIF-A and -D, varying considerably in their abilities to inhibit plaque formation by different viruses in a range of mammalian cells. All six of the cloned LeIFs exhibit the heat stability, pH 2 stability and antigenic specificity of natural leukocyte interferons.

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Citations

Jun 15, 1989·Experientia·K E MogensenP Eid
Jan 1, 1984·Pharmacology & Therapeutics·S A NarangF Georges
Jan 1, 1985·Pharmacology & Therapeutics·P B Fisher, S Grant
Jan 1, 1985·Pharmacology & Therapeutics·J A Langer, S Pestka
Jun 1, 1995·Pharmacology & Therapeutics·M A Horisberger, S Di Marco
Jul 1, 1994·Antiviral Research·J D GangemiJ W Kreider
Sep 5, 2002·Veterinary Immunology and Immunopathology·Ramani WonderlingMichael Milhausen
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P SlocombeD C Burke
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P W Gray, D V Goeddel
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J S PattonC Grunfeld
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E Ishizaka-IkedaS Nagata
Jan 1, 1984·Biotechnology & Genetic Engineering Reviews·M D Edge, R Camble
Mar 1, 1984·The Journal of Experimental Medicine·L P SvederskyM A Palladino
Nov 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K E MogensenG Uzé
Mar 25, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G GribaudoS Landolfo
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Feb 11, 1983·Nucleic Acids Research·G D ShawC Weissmann
Feb 1, 1988·European Journal of Biochemistry·G UzeK E Mogensen

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