Antiviral activities of resveratrol against rotavirus in vitro and in vivo

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Haohai HuangRong Pu

Abstract

Rotavirus (RV) is the primary causative agent for viral gastroenteritis among infants and young children worldwide. Currently, no clinically approved and effective antiviral drug for the treatment of RV infection is available. We investigated the potential anti-RV activity of resveratrol and underlying mechanisms by which resveratrol acted against RV. The anti-RV activity of resveratrol in vitro was evaluated using plaque reduction assays. The effects of resveratrol on yield of virion progeny, viral polyprotein expression and genomic RNA synthesis were respectively investigated using enzyme-linked immunosorbent assays, western blotting and qRT-PCR assays. Further, we also measured the antiviral effect of resveratrol by evaluation of antigen clearance and assessment of changes in proinflammatory cytokines/chemokines in RV-infected neonatal mouse model. Our results indicated that 20 μM of resveratrol significantly inhibited RV replication in Caco-2 cell line by suppressing RV RNA synthesis, protein expression, viroplasm plaque formation, progeny virion production, and RV-induced cytopathy independent of the different strains and cell lines of RV that we used. Analysis of the effect of time post-addition of resveratrol indicated t...Continue Reading

Citations

Feb 17, 2021·Phytotherapy Research : PTR·Sofi Imtiyaz AliShowkat Ul Nabi
Mar 7, 2021·Viruses·Sébastien PasquereauGeorges Herbein
Mar 7, 2021·Biomedicines·Natalya N BesednovaMikhail Yu Shchelkanov
Apr 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ehsan AbediniHossein Samadi Kafil
Jan 1, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Partha PalitNima Rezaei
May 1, 2021·Pharmaceuticals·Tapan BehlDomenico Montesano
Jul 21, 2021·Molecular Biology Reports·Constanza A RussoCybele C García

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