Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19

Open Forum Infectious Diseases
Jun ChenHongzhou Lu

Abstract

We aimed to evaluate the antiviral activity and safety of darunavir/cobicistat (DRV/c) in treating COVID-19 patients. In this single-center, randomized, and open-label trial, mild patients with polymerase chain reaction (PCR)-confirmed COVID-19 were enrolled in Shanghai, China. Participants were randomized to receive DRV/c for 5 days on the top of interferon alpha 2b inhaling or interferon alpha 2b inhaling alone. The primary end point was the virological clearance rate of oropharyngeal swabs at day 7 after randomization in the intention-to-treat population (clinicaltrials.gov: NCT04252274). From January 30, 2020, to February 6, 2020, a total of 30 patients were enrolled, of whom 18 (60%) were male, aged 47.2 ± 2.8 years; 63.3% (19/30) of the participants had fever, and 46.7% (14/30) had cough at enrollment. The participants were randomized (range) at 4 (2-5) days after onset of symptoms. The proportion of negative PCR results at day 7 was 46.7% (7/15) and 60.0% (9/15) in the DRV/c and control groups (P = .72), respectively. The viral clearance rate at day 3 was 20% (3/15) in both study groups, while the number increased to 26.7% (4/15) in the DRV/c group and remained 20% (3/15) in the control group at day 5. Fourteen days afte...Continue Reading

Associated Clinical Trials

References

Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang

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Citations

Sep 13, 2020·Journal of the Pediatric Infectious Diseases Society·Kathleen ChiotosMari M Nakamura
Nov 21, 2020·Journal of Clinical Pharmacology·Golbarg AlavianZahra Sadat Torabi
Dec 6, 2020·Medicinal Research Reviews·Jimin XuJia Zhou
Jan 9, 2021·Journal of Biomolecular Structure & Dynamics·M Elizabeth SobhiaHarmanpreet Singh
Dec 15, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Monica FungJennifer Babik
Jan 27, 2021·Cells·Rameswari Chilamakuri, Saurabh Agarwal
Dec 30, 2020·International Journal of Molecular Sciences·Jung-Hyun Won, Howard Lee
Jan 15, 2021·Journal of Experimental Pharmacology·Pasquale PaglianoAmelia Filippelli
Feb 24, 2021·AIDS Research and Human Retroviruses·Jovana MilicGiovanni Guaraldi
Feb 27, 2021·Expert Opinion on Pharmacotherapy·María Del Mar GutierrezPere Domingo
Feb 28, 2021·European Journal of Pharmacology·Priyasha DeNirmal Mazumder
Feb 23, 2021·Frontiers in Immunology·Ching-Hsuan LiuLiang-Tzung Lin
Feb 20, 2021·Life Sciences·Ajaikumar B KunnumakkaraBharat B Aggarwal
Mar 19, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Tobias WelteIan Sabir
Feb 20, 2021·Current Opinion in Pulmonary Medicine·Kevin C Wilson
Mar 31, 2021·Virology Journal·Zachary A KrummYuxing Xia
Mar 21, 2021·International Journal of Clinical Practice·Muhammet Ali OruçOnur Öztürk
Apr 18, 2021·Journal of Molecular Modeling·Debarati PaulShubhra Ghosh Dastidar
May 1, 2021·Infectious Disease Reports·Feras JirjeesYahya H Dallal Bashi
Apr 19, 2021·The Lancet Global Health·Jay J H ParkEdward J Mills
May 8, 2021·British Journal of Pharmacology·Cristina ScavoneAnnalisa Capuano
Jun 1, 2021·Frontiers in Molecular Biosciences·Miao Mei, Xu Tan
Jun 13, 2021·Journal of Infection and Public Health·Vartika Srivastava, Aijaz Ahmad
Jun 29, 2021·Frontiers in Medicine·Augusto Di CastelnuovoUNKNOWN COVID-19 RISK and Treatments (CORIST) Collaboration
Jul 14, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chih-Cheng LaiPo-Ren Hsueh
Jul 30, 2021·Expert Review of Anti-infective Therapy·George N OkoliAhmed M Abou-Setta
Aug 19, 2021·Cell Death and Differentiation·Marcello AllegrettiEmanuele Nicastri
Oct 14, 2021·Journal of Chemotherapy·M VitroneR Zampino
Nov 11, 2021·Future Microbiology·Sarah AherfiDidier Raoult
Nov 12, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Pooria AsiliBagher Larijani

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT04252274

Software Mentioned

STATA

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