PMID: 8585764Oct 1, 1995Paper

Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs

Antiviral Research
R F AzadK P Anderson

Abstract

ISIS 2922 is a phosphorothioate oligonucleotide with potent antiviral activity against human cytomegalovirus (HCMV) in cell culture assays. The ability of ISIS 2922 to inhibit replication of HCMV when used in combination with other antiviral agents approved for treatment of HCMV disease was investigated using a 96-well immunoassay. The antiviral activity of ISIS 2922 against HCMV was additive with that of ganciclovir (9-(1,3-dihydroxy-2-propoxymethylguanine); DHPG) or foscarnet (phosphonoformate). Compounds used clinically for the treatment of human immunodeficiency virus infection and likely to be co-administered with ISIS 2922 in the clinic were also evaluated for their ability to modulate the antiviral activity of ISIS 2922. 3'-Azido-3'-deoxythymidine (AZT) exhibited no antiviral activity against HCMV in the 96-well immunoassay, and did not significantly alter the antiviral activity of ISIS 2922. 2'-3'-Dideoxycytidine (ddC) was able to inhibit replication of HCMV at high doses, and this activity was additive with that of ISIS 2922. ISIS 2922 inhibited HIV replication in acute infection assays at relatively high concentrations as previously reported for non-complementary phosphorothioate oligonucleotides. When ISIS 2922 was u...Continue Reading

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Citations

Feb 16, 2000·Progress in Retinal and Eye Research·A BochotE Fattal
Oct 4, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Phong TrangFenyong Liu
May 19, 2000·Antimicrobial Agents and Chemotherapy·M MarschallT Stamminger
Apr 30, 2002·Clinical Pharmacokinetics·Richard S GearyLisa R Grillone
Oct 1, 2008·Expert Opinion on Drug Discovery·Ravinder Malik, Ipsita Roy
Sep 1, 2008·Expert Opinion on Drug Discovery·Douglas W Leaman
Apr 14, 2015·Annals of the New York Academy of Sciences·Carol Davies-SalaMarcelo E Tolmasky
Nov 14, 2006·Advanced Drug Delivery Reviews·Elias Fattal, Amélie Bochot
Nov 26, 1999·Antiviral Chemistry & Chemotherapy·A K Field
Sep 10, 2009·Chembiochem : a European Journal of Chemical Biology·Neil M Bell, Jason Micklefield
Dec 28, 1999·Ocular Immunology and Inflammation·M D de SmetG J van den Horn

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