Antiviral activity of fattiviracin FV-8 against human immunodeficiency virus type 1 (HIV-1)

Bioscience, Biotechnology, and Biochemistry
E E HabibMasaru Uyeda

Abstract

A novel antiviral agent, fattiviracin FV-8, purified from the culture broth of Streptomyces microflavus strain No. 2445, showed potent antiviral activities against human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and influenza A and B viruses. The action mechanism of fattiviracin FV-8 against HIV-1 was examined. As a result, the agent was thought to act on HIV-1 particles directly without lysis of the particles, and it affords the inhibition of viral entry into the host cells.

References

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Jan 8, 1997·JAMA : the Journal of the American Medical Association·S G DeeksJ O Kahn
Feb 24, 2001·The Journal of Antibiotics·E S HabibM Uyeda

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Citations

Apr 5, 2011·Natural Product Research·K SuthindhiranA S Sahul Hameed
Nov 14, 2014·Viruses·Natapong JupatanakulGeorge Dimopoulos
Jan 16, 2007·Cellular Microbiology·Shinji HaradaKeisuke Yusa
Aug 7, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masaru Uyeda
Oct 23, 2003·Journal of the American Chemical Society·Alois FürstnerErik DeClercq

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