PMID: 7535992Dec 1, 1994Paper

Antiviral activity of natural and semi-synthetic chromone alkaloids

Antiviral Research
P J HoughtonN Mahmood

Abstract

The activity against human immunodeficiency virus (HIV) and herpes simplex virus (HSV), of the non-polar fraction of a methanolic extract of the rootbark of Schumanniophyton magnificum was found to be present in a fraction containing the chromone secondary amine schumannificine 1. Other chromone alkaloids present in the plant were isolated and tested for inhibition of HIV and HSV infections in C8166 and Vero cells, respectively. Acyl and methyl derivatives were prepared and tested. Of all the compounds tested, schumannificine 1 displayed the greatest activity against HIV, whereas potent anti-HSV activity was observed for a number of its derivatives. The presence of a piperidine ring and unsubstituted hydroxy groups on the molecules seems to favour the anti-HIV activity. The anti-HIV activity is considered to be due to irreversible binding to gp120 rather than inhibition of reverse transcriptase or protease.

References

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Citations

Nov 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·P J Houghton
Mar 14, 2002·Journal of Ethnopharmacology·Kavita Vermani, Sanjay Garg
Apr 3, 2014·European Journal of Medicinal Chemistry·Rangappa S KeriR Geetha Balakrishna
Jun 3, 2014·The Journal of Organic Chemistry·Inna Vints, Shlomo Rozen
Mar 10, 2006·Bioorganic Chemistry·Xueshu LiYufen Zhao
Mar 26, 2019·Plant Biotechnology Journal·Peyman HabibiMaria Fatima Grossi-de-Sa
Aug 25, 2020·Pharmaceutical Chemistry Journal·Noor Ul Amin MohsinUsman Saleem
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Jun 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Bagher MajnooniJavier Echeverría
Jul 7, 2018·Journal of Agricultural and Food Chemistry·Jian ChengGuan-Hu Bao

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