Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
K. S. PlanteRobert A Newman

Abstract

With continued expansion of the coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), both antiviral drugs as well as effective vaccines are desperately needed to treat patients at high risk of life-threatening disease. Here, we present in vitro evidence for significant inhibition of SARS-CoV-2 by oleandrin and a defined extract of N. oleander (designated as PBI-06150). Using Vero cells, we found that prophylactic (pre-infection) oleandrin (as either the pure compound or as the active principal ingredient in PBI-06150) administration at concentrations as low as 0.05 µg/ml exhibited potent antiviral activity against SARS-CoV-2, with an 800-fold reduction in virus production, and a 0.1 µg/ml concentration resulted in a greater than 3000-fold reduction in infectious virus production. The half maximal effective concentration (EC50) values were 11.98 ng/ml when virus output was measured at 24 h post-infection, and 7.07 ng/ml measured at 48 h post-infection. Therapeutic (post-infection) treatment up to 24 h after SARS-CoV-2 infection of Vero cells also reduced viral titers, with 0.1 µg/ml and 0.05 µg/ml concentrations causing greater than 100-fold reduction as measured at 48 h, and the 0...Continue Reading

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Citations

Jun 19, 2021·Journal of the American College of Emergency Physicians Open·R Newman, K Jagannadha Sastry
Jul 14, 2021·The Journal of Organic Chemistry·Zachary FejedelemPavel Nagorny
Jul 24, 2021·Journal of Chemical Information and Modeling·Jacob Al-SaleemQiongqiong Zhou

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Datasets Mentioned

BETA
MN985325.1
MT020880

Methods Mentioned

BETA
sedation
ELISA
transgenic

Software Mentioned

Prism
GraphPad
Gen5

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