Antiviral Activity of Peanut (Arachis hypogaea L.) Skin Extract Against Human Influenza Viruses

Journal of Medicinal Food
J N MakauNoriyuki Nishida

Abstract

The high propensity of influenza viruses to develop resistance to antiviral drugs necessitates the continuing search for new therapeutics. Peanut skins, which are low-value byproducts of the peanut industry, are known to contain high levels of polyphenols. In this study, we investigated the antiviral activity of ethanol extracts of peanut skins against various influenza viruses using cell-based assays. Extracts with a higher polyphenol content exhibited higher antiviral activities, suggesting that the active components are the polyphenols. An extract prepared from roasted peanut skins effectively inhibited the replication of influenza virus A/WSN/33 with a half maximal inhibitory concentration of 1.3 μg/mL. Plaque assay results suggested that the extract inhibits the early replication stages of the influenza virus. It demonstrated activity against both influenza type A and type B viruses. Notably, the extract exhibited a potent activity against a clinical isolate of the 2009 H1N1 pandemic, which had reduced sensitivity to oseltamivir. Moreover, a combination of peanut skin extract with the anti-influenza drugs, oseltamivir and amantadine, synergistically increased their antiviral activity. These data demonstrate the potential a...Continue Reading

References

May 1, 1980·Antimicrobial Agents and Chemotherapy·F G HaydenR G Douglas
Nov 7, 1999·Antiviral Research·J J DochertyA L DeLucia
Dec 3, 1999·The American Journal of Clinical Nutrition·E B Feldman
Apr 25, 2000·Journal of Agricultural and Food Chemistry·T H SandersK W Hendrix
Jul 13, 2000·Nutrition and Cancer·A B AwadC S Fink
Jul 18, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C M Alper, R D Mattes
Nov 5, 2004·World Journal of Gastroenterology : WJG·Ming-Ming ZhangLin He
Jan 8, 2005·Journal of the American College of Nutrition·Amy E GrielPenny M Kris-Etherton
Apr 20, 2005·The Journal of Infectious Diseases·Anna T PalamaraEnrico Garaci
Sep 3, 2005·Antiviral Research·Jae-Min SongBaik-Lin Seong
Jun 16, 2007·The Journal of Infectious Diseases·Varough M DeydeAlexander I Klimov
Apr 1, 2009·Emerging Infectious Diseases·Adam MeijerUNKNOWN European Influenza Surveillance Scheme
Jan 26, 2011·Annals of the New York Academy of Sciences·Ketan R PatelKaren Brown
Sep 9, 2011·Current Opinion in Microbiology·Michael A Fischbach
Aug 1, 2010·Viruses·Elena A Govorkova, Robert G Webster
Jan 26, 2012·Current Opinion in HIV and AIDS·James L ReadingAnnapurna Vyakarnam
May 19, 2012·Pathogens and Global Health·Maria Grazia AmmendoliaFabiana Superti
Jan 16, 2014·Drug Discoveries & Therapeutics·T IchinoseN Kobayashi
Jun 1, 2014·Archives of Medical Research·Ken WatanabeNobuyuki Kobayashi
Sep 4, 2014·Journal of Medicinal Food·Rishipal R BansodeJianmei Yu
Dec 23, 2015·Advances in Virology·Yusuf AbbaMohamed Mustapha Noordin
Jan 21, 2016·Journal of Food Science and Technology·Shalini S AryaS Chauhan

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Citations

Jul 18, 2020·Medicinal Research Reviews·Zhi-Jun ZhangRong-Tao Li
Jan 1, 2019·Critical Reviews in Food Science and Nutrition·Ondulla T Toomer
Dec 21, 2019·Phytotherapy Research : PTR·Marcella DenaroDomenico Trombetta
Aug 28, 2020·Frontiers in Medicine·Farhana Rumzum BhuiyanMahmudul Hasan
May 11, 2021·Journal of Food Science and Technology·Ahmed Mohamed HamedEsmat Aly

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