PMID: 8585761Sep 1, 1995Paper

Antiviral activity of recombinant interferon-alpha on hepatitis A virus replication in human liver cells

Antiviral Research
J M CranceR Deloince

Abstract

Human recombinant interferon-alpha (IFN-alpha) was assayed for its antiviral effect on hepatitis A virus (HAV) replication in the human hepatoma cell line PLC/PRF/5. IFN-alpha resulted in concentration-dependent reduction of HAV antigen expression and HAV replication. IFN-alpha had a prophylactic effect, but was still effective when it was added after the infection, even at the end of the first replication cycle. An important increase in 2',5'-oligoadenylate synthetase activity in the IFN-treated human liver cells was observed. The antiviral effect of IFN-alpha could be attributed to the induction of this enzyme. Moreover we have shown that IFN-alpha and glycyrrhizin were synergistic in their antiviral actions against HAV. IFN-alpha emerged, from the present study, as a promising candidate for chemotherapy of severe forms of hepatitis A.

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Citations

Jan 18, 2006·Journal of Virology·Krishnamurthy Konduru, Gerardo G Kaplan
Apr 27, 2005·Biochemical and Biophysical Research Communications·Tatsuo KandaHiromitsu Saisho
May 6, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Min Hwa LeeChangsun Choi
Jun 22, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsuo KandaOsamu Yokosuka
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Yun-Fan Liaw
Jun 1, 2013·Medicinal Research Reviews·Yannick DebingHendrik Jan Thibaut
Aug 23, 2016·Journal of the Science of Food and Agriculture·Ntshepisa LebetwaShigeru Katayama
May 16, 2020·Viruses·Tatsuo KandaMitsuhiko Moriyama
Aug 10, 2021·World Journal of Gastroenterology : WJG·Pietro TorreMarcello Persico

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