PMID: 11924766Apr 2, 2002Paper

Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1)

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
P CosA J Vlietinck

Abstract

Selected plants used in Rwandan traditional medicine for the treatment of infections and/or rheumatoid diseases were investigated for antiviral activity in vitro against human immunodeficiency virus type-1 (HIV-1). Of the 38 tested 80% ethanolic extracts, belonging to plants of 21 different families only the extracts from the leaves of Aspilia pluriseta (Asteraceae) and Rumex bequaertii (Polygonaceae) had interesting selectivity indices (SI = ratio of the 50% cytotoxic concentration to the 50% effective antiviral concentration) higher than 1. Further fractionation of the initially antivirally inactive ethanolic extract of Tithonia diversifolia, however, led to an aqueous fraction with a high anti-HIV-1 activity (SI > 461), indicating that the cytotoxicity of some plant components may mask the antiviral properties of the active plant substances in total plant extracts.

Citations

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Feb 15, 2013·PloS One·Jean de Dieu TamokouRadu Silaghi-Dumitrescu
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