Antiviral and antituberculous activity of Helichrysum melanacme constituents

Fitoterapia
N LallJ J M Meyer

Abstract

Bioassay guided fractionation of the acetonic extract of Helichrysum melanacme using human Influenza virus type A and a drug-sensitive strain of Mycobacterium tuberculosis in vitro resulted in the isolation of 2 4',6'-trihydroxy-3'-prenylchalcone (1) and 4',6',5''-trihydroxy-6'',6''-dimethyldihydropyrano[2'',3''-2',3'] chalcone (2) as active constituents. 3-O-methylquercetin and quercetin were also isolated but were inactive against the microorganisms tested in this study.

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Citations

Nov 3, 2009·Chemical & Pharmaceutical Bulletin·Seyed Mahdi ZiaratniaJacobus Johannes Marion Meyer
Jun 30, 2014·BMC Complementary and Alternative Medicine·Rafaele C P AraujoJulio Croda
Nov 14, 2015·Assay and Drug Development Technologies·Shrouq I FarahHarsh Chauhan
Jan 28, 2012·European Journal of Medicinal Chemistry·Abraham GarcíaGildardo Rivera
Sep 23, 2008·Journal of Ethnopharmacology·L J McGawJ N Eloff
Feb 27, 2009·Human & Experimental Toxicology·Ee ElgorashiJ van Staden
Dec 31, 2020·Biomolecules·Parvaneh MehrbodSaeid Ghavami

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