Antiviral anticoagulation.

Research and Practice in Thrombosis and Haemostasis
Edward L G PryzdialMarc S Horwitz

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel envelope virus that causes coronavirus disease 2019 (COVID-19). Hallmarks of COVID-19 are a puzzling form of thrombophilia that has elevated D-dimer but only modest effects on other parameters of coagulopathy. This is combined with severe inflammation, often leading to acute respiratory distress and possible lethality. Coagulopathy and inflammation are interconnected by the transmembrane receptor, tissue factor (TF), which initiates blood clotting as a cofactor for factor VIIa (FVIIa)-mediated factor Xa (FXa) generation. TF also functions from within the nascent TF/FVIIa/FXa complex to trigger profound changes via protease-activated receptors (PARs) in many cell types, including SARS-CoV-2-trophic cells. Therefore, aberrant expression of TF may be the underlying basis of COVID-19 symptoms. Evidence suggests a correlation between infection with many virus types and development of clotting-related symptoms, ranging from heart disease to bleeding, depending on the virus. Since numerous cell types express TF and can act as sites for virus replication, a model envelope virus, herpes simplex virus type 1 (HSV1), has been used to investigate the uptake of TF into ...Continue Reading

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Citations

Aug 8, 2020·Journal of Thrombosis and Haemostasis : JTH·Edward M Conway, Edward L G Pryzdial
Sep 13, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Rami A Al-Horani
Sep 19, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Aining ZhangZhongyuan Xia
Oct 13, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Takefumi Kimura, Ho Namkoong
Jun 4, 2021·Journal of Thrombosis and Thrombolysis·Oktay Gülcüİbrahim Halil Tanboğa

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Methods Mentioned

BETA
transgenic

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