Antiviral approaches for cancers related to Epstein-Barr virus and human papillomavirus

The Lancet Oncology
Bassam Abdulkarim, Jean Bourhis

Abstract

Epstein-Barr virus and human papillomaviruses (HPV) are DNA viruses underlying the carcinogenesis of 15-20% of human cancers worldwide. Viral oncoproteins are involved in malignant transformation and maintenance of the malignant phenotype, mainly through interaction between oncoproteins and products of tumour-suppressor genes. The use of vaccines to prevent the occurrence of HPV-related cancers is being investigated. Several approaches have been used to inhibit expression of viral oncoproteins. The first strategy uses antisense oligodeoxynucleotides against viral oncoproteins; downregulation of the oncoproteins can influence tumour cell growth and restore sensitivity to cytotoxic agents. Another approach uses antiviral drugs such as acyclic nucleoside phosphonates; inhibition of virus replication can lead to downregulation of viral oncoproteinsand ultimately reactivate tumour-suppressor-gene pathways. In addition, the combination of acyclic nucleoside phosphonates with conventional cytotoxic agents is more effective than either agent alone. These data provide the basis for a novel anticancer strategy to improve the therapeutic ratio in virus-related cancers, which needs to be further investigated for clinical applications.

References

Jul 9, 1991·International Journal of Cancer. Journal International Du Cancer·I JoabY Zeng
Nov 22, 1991·Science·H zur Hausen
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·V BandR Sager
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K GilliganN Raab-Traub
Feb 23, 1989·The New England Journal of Medicine·L M WeissJ Sklar
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·R PauwelsE De Clercq
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·N Raab-TraubJ Pagano
Oct 2, 1986·Nature·E De ClercqP C Maudgal
Sep 15, 1983·International Journal of Cancer. Journal International Du Cancer·D J MossN Kunaratnam
Dec 1, 1983·Journal of Virology·N Raab-TraubJ S Pagano
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J YatesB Sugden
Jan 1, 1994·Intervirology·H StöpplerR Schlegel
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S HendersonA Rickinson
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KayeE Kieff
Jan 14, 1998·International Journal of Cancer. Journal International Du Cancer·S S MagalL Sherman
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·W KulwichitN Raab-Traub
Jan 9, 1999·Oncogene·M Thomas, L Banks
May 14, 1999·Molecular Medicine Today·J T Schiller
May 21, 1999·Journal of Immunotherapy·M MurakamiM A Steller
Mar 14, 2000·Seminars in Cancer Biology·F Breitburd, P Coursaget
May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·S HietanenD P Lane
Aug 17, 2000·The New England Journal of Medicine·J I Cohen
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C Goodwin, D DiMaio

❮ Previous
Next ❯

Citations

Jun 7, 2003·International Journal of Antimicrobial Agents·Mark Wainwright
Nov 21, 2012·Infectious Agents and Cancer·Kenneth AlibekBolat Sultankulov
Jan 30, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·N MagnéC Haie-Meder
Oct 17, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Assis EckerNilda Vargas Barbosa
Mar 28, 2017·Infectious Agents and Cancer·Madina ShaimerdenovaDana Akilbekova
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew P Thompson, Razelle Kurzrock
Mar 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Abhik Saha, Erle S Robertson

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.