Antiviral CD8-mediated responses in chronic HCV carriers with HBV superinfection

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Carolina BoniCarlo Ferrari

Abstract

Hepatitis B virus (HBV) superinfection in chronic hepatitis C represents a natural model to investigate whether or not hepatitis C virus (HCV) can influence priming and maturation of antiviral T cells; whether or not HBV superinfection, which is known to determine control of HCV replication, can restore HCV-specific T cell responsiveness; and whether or not cytokines stimulated by HBV infection can contribute to HCV control. To address these issues, the function of CD8 cells specific for HBV and HCV was studied longitudinally in two chronic HCV patients superinfected with HBV. Patients with acute hepatitis B were also examined. Frequency and function of HBV tetramer+ CD8 cells were comparable in patients acutely infected with HBV with or without chronic HCV infection. HBV-specific CD8 cell function was efficiently expressed irrespective of serum HCV-RNA levels. Moreover, fluctuations of HCV viremia at the time of HBV superinfection were not associated with evident changes of CD8 responsiveness to HCV. Finally, no correlation was found between serum levels of interferon alpha, interleukin (IL)-12, IL-10, or IL-18 and control of HCV replication. In conclusion, HCV did not affect the induction of primary and memory HBV-specific CD...Continue Reading

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Citations

Mar 2, 2005·Nature Reviews. Immunology·Barbara Rehermann, Michelina Nascimbeni
Mar 9, 2005·The Journal of Experimental Medicine·Simona UrbaniCarlo Ferrari
Nov 14, 2006·European Journal of Gastroenterology & Hepatology·Lan LinJohan Fevery
Jun 10, 2008·The Journal of Infection·E BiliottiG Taliani
Feb 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simona UrbaniCarlo Ferrari
Feb 12, 2008·Reviews in Medical Virology·Vicente CarreñoJuan Antonio Quiroga
Aug 30, 2006·Scandinavian Journal of Infectious Diseases·Wolfgang JessnerWolfgang Vogel
Mar 13, 2020·The Journal of Clinical Investigation·Xiaoming ChengT Jake Liang
Oct 31, 2014·World Journal of Gastroenterology : WJG·Gaia CaccamoGiovanni Raimondo

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