Antiviral CD8 T cells recognize borna disease virus antigen transgenically expressed in either neurons or astrocytes

Journal of Virology
Karen BaurPeter Staeheli

Abstract

Borna disease virus (BDV) can persistently infect the central nervous system (CNS) of mice. The infection remains nonsymptomatic as long as antiviral CD8 T cells do not infiltrate the infected brain. BDV mainly infects neurons which reportedly carry few, if any, major histocompatibility complex class I molecules on the surface. Therefore, it remains unclear whether T cells can recognize replicating virus in these cells or whether cross-presentation of viral antigen by other cell types is important for immune recognition of BDV. To distinguish between these possibilities, we used two lines of transgenic mice that strongly express the N protein of BDV in either neurons (Neuro-N) or astrocytes (Astro-N). Since these animals are tolerant to the neo-self-antigen, we adoptively transferred T cells with specificity for BDV N. In nontransgenic mice persistently infected with BDV, the transferred cells accumulated in the brain parenchyma along with immune cells of host origin and efficiently induced neurological disease. Neurological disease was also observed if antiviral T cells were injected into the brains of Astro-N or Neuro-N but not nontransgenic control mice. Our results demonstrate that CD8 T cells can recognize foreign antigen ...Continue Reading

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Citations

Oct 6, 2009·Seminars in Immunopathology·Bettina SchreinerBurkhard Becher
Apr 11, 2009·The American Journal of Pathology·Kirsten RichterPeter Staeheli
Dec 12, 2012·The Journal of General Virology·Paula M KinnunenOlli Vapalahti
Jul 20, 2010·Immunotherapy·Nagendra R HegdeSrinivas V Kaveri

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