Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): retroviruses and hepadnaviruses

Antiviral Chemistry & Chemotherapy
Erik De Clercq, Hugh J Field

Abstract

There are at present exactly 25 compounds that have been formally approved for the treatment of retrovirus (that is HIV) infections: seven nucleoside reverse transcriptase inhibitors (NRTIs), one nucleotide reverse transcriptase inhibitor (NtRTI), four non-nucleoside reverse transcriptase inhibitors (NNRTIs), 10 protease inhibitors (PIs), one coreceptor inhibitor (CRI), one fusion inhibitor (FI) and one integrase inhibitor (INI). Other compounds expected to be approved for the treatment of HIV infections in the near future are the NNRTI rilpivirine, the CRI vicriviroc and the INI elvitegravir. To obtain synergistic activity, enable lower dosage levels, thus minimizing toxic side effects, and particularly to reduce the risk of drug resistance development, common wisdom dictates that the HIV inhibitors should be used in drug combination regimens. Although, given the number of compounds available, the drug combinations that could be concocted are uncountable, only one triple-drug combination has so far been formulated as single pill to be taken orally once daily, namely Atripla containing the NtRTI tenofovir disoproxil fumarate, the NRTI emtricitabine and the NNRTI efavirenz. Here, we document these approved compounds along with o...Continue Reading

References

Sep 1, 1978·Science·E HelgstrandB Oberg
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M W FriedJ H Hoofnagle
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L DoongY C Cheng
Mar 1, 1990·Journal of Medicinal Chemistry·V E MarquezJ S Driscoll
Apr 20, 1990·Science·N A RobertsA Kröhn
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·R PauwelsE De Clercq
Sep 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·F BironJ Vila
May 1, 1993·Antimicrobial Agents and Chemotherapy·T J DuewekeL Resnick
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·S H ReichH Dawson
Jun 1, 1995·Annals of Internal Medicine·J P IoannidisH S Sacks
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·E De ClercqR Datema
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·J P VaccaE Roth
May 1, 1996·AIDS Research and Human Retroviruses·M VandeveldeJ P Tassignon
Jan 1, 1996·Antimicrobial Agents and Chemotherapy·S RusconiM S Hirsch

❮ Previous
Next ❯

Citations

Oct 21, 2016·Nucleosides, Nucleotides & Nucleic Acids·Nahid ShahabadiNeda Hosseinpour Moghadam
Jan 25, 2013·Antiviral Chemistry & Chemotherapy·Erik De Clercq

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

© 2022 Meta ULC. All rights reserved