Antiviral drops: comparative therapy of experimental herpes simplex keratouveitis

Archives of Ophthalmology
D Pavan-LangstonR Campbell

Abstract

The present, masked, controlled study compares the therapeutic efficacy of guttate 3% vidarabine, 0.1% idoxuridine, and 1% trifluridine in herpes simplex keratouveitis in rabbits. Vidarabine, whether given every hour, every two hours, or every three hours was significantly better than controls but significantly worse than idoxuridine or trifluridine. Trifluridine and idoxuridine were not significantly different from each other. Viral cultures taken at the end of the six-day treatment period were positive in the majority of all treatment groups except for the trifluridine group, which was 100% negative. Although previous studies have shown that vidarabine is very effective as an antiviral ointment, vidarabine drops are not as effective as guttate idoxuridine or trifluridine.

Citations

Apr 12, 2001·Contact Dermatitis·M R Holdiness

Related Concepts

Metazoa
Idoxuridine, Radical Ion (1-)
Keratitis, Dendritic
Ophthalmic Solution
Chinchilla Rabbits
Thymidine
Triflumann
Uveitis
Vira-A

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
A PandaV Rao
Annals of Ophthalmology
D Pavan-LangstonP A Geary
© 2021 Meta ULC. All rights reserved