PMID: 9420052Jan 7, 1998Paper

Antiviral drug susceptibility of human herpesvirus 8

Antimicrobial Agents and Chemotherapy
J Neyts, E De Clercq

Abstract

We studied the susceptibility of human herpesvirus 8 (HHV-8) to a number of antiherpesvirus agents. The acyclic nucleoside phosphonate (ANP) analogs cidofovir and HPMPA [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine] effected potent inhibition of HHV-8 DNA synthesis, with 50% effective concentrations (EC50) of 6.3 and 0.6 microM, respectively. Adefovir, an ANP with both antiretrovirus and antiherpesvirus activity, blocked HHV-8 DNA replication at a fourfold-lower concentration than did foscarnet (EC50 of 39 and 177 microM, respectively). The most potent inhibitory effect was obtained with the N-7-substituted nucleoside analog S2242 (EC50, 0.11 microM). The nucleoside analogs acyclovir, penciclovir, H2G ((R)-9-[4-hydroxy-2-(hydroxymethyl) butyl]guanine), and brivudine had weak to moderate effects (EC50 of > or =75, 43, 42, and 24 microM, respectively, and EC90 of > or =75 microM), whereas ganciclovir elicited pronounced anti-HHV-8 activity (EC50, 8.9 microM).

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Citations

Nov 3, 2005·Nature Reviews. Drug Discovery·Erik De Clercq, Antonín Holý
Jan 13, 2004·Nucleosides, Nucleotides & Nucleic Acids·Nicole L KushnerEarl R Kern
Nov 22, 2014·QJM : Monthly Journal of the Association of Physicians·A KlepfishA Schattner
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas B CampbellLovemore Gwanzura
Jan 6, 1999·Antiviral Chemistry & Chemotherapy·A MeerbachJ Neyts
Nov 26, 2014·Viruses·Natacha CoenGraciela Andrei
Oct 17, 2012·The Korean Journal of Hematology·Ibrahiem Saeed-Abdul-Rahman, Ali M Al-Amri
Oct 3, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Irfan Ali R KugasiaOleg Epelbaum
Jul 11, 2008·Reviews in Medical Virology·Corey Casper
Dec 20, 2005·The Journal of Pathology·Thomas F Schulz
Jun 15, 2011·Current Opinion in Infectious Diseases·Soren Gantt, Corey Casper
Apr 5, 2001·Current Infectious Disease Reports·Nina Singh
Sep 25, 2014·MBio·Mina C HosseinipourDirk P Dittmer
Apr 6, 2000·The New England Journal of Medicine·K Antman, Y Chang
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·S LiekensJ Neyts
Oct 1, 2014·Antimicrobial Agents and Chemotherapy·Natacha CoenGraciela Andrei
Sep 20, 2002·Journal of Virology·Gábor GáspárJohan Neyts
Sep 24, 2002·Revista do Hospital das Clínicas·Jair Carneiro LeãoCrispian Scully
Sep 11, 2003·Journal of Medical Virology·Sanjaya SenanayakeWilliam Rawlinson
Jun 30, 2005·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G VerucchiM Bernardi
Jul 17, 2004·Cancer Research·Michelle R StaudtDirk P Dittmer
Sep 25, 2004·Medicinal Research Reviews·Erik De Clercq
Aug 12, 2005·Current Opinion in Oncology·Carmen Manuela Klass, Margaret K Offermann
May 22, 2008·The Journal of Infectious Diseases·Clyde S Crumpacker
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Stephanie L Williams-AzizEarl R Kern
Mar 29, 2011·The Oncologist·Hazem E El-Osta, Razelle Kurzrock
Jul 15, 2006·Nucleosides, Nucleotides & Nucleic Acids·Masahiro FujimuroHideyoshi Yokosawa
Dec 18, 2001·Reviews in Medical Virology·E De ClercqJ Neyts
Sep 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Giuseppe MariggiòThomas F Schulz
Apr 20, 2002·Current Opinion in Infectious Diseases·Nina Singh

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