Antiviral Drugs Targeting Influenza Virus Surface Proteins: A Computational Structural Biology Approach

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Manabu Igarashi

Abstract

For the prevention and control of infectious viral diseases, vaccines and antiviral drugs targeting viral proteins are of great importance. Amino acid substitutions in viral proteins occasionally cause the emergence of antibody-escape and drug-resistant mutants. With regard to this, we have studied the proteins of several viruses, especially the influenza A virus, by using techniques of computational chemistry and biology such as molecular modeling, molecular docking, and molecular dynamics simulations. Influenza A virus is a zoonotic pathogen that is transmitted from animals to humans. This virus has two surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). The HA of influenza viruses plays a key role in the initiation of viral infection. And HA is also the major target of antibodies that neutralize viral infectivity. Some amino acid substitutions in the antigenic epitope on HA could decrease the interaction between HA and antibodies, leading to the generation of antigenic variants with novel antigenic structures of HA. In addition, HA protein seems to be a favorable target for anti-influenza drugs, but effective HA inhibitors have not been developed due to the emergence of drug-resistant viruses with amino acid su...Continue Reading

References

Aug 1, 1997·The Journal of Infectious Diseases·E D Kilbourne
Sep 18, 1999·Lancet·M PeirisK F Shortridge
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Barry R O'KeefeMichael R Boyd
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ron A M FouchierAlbert D M E Osterhaus
Feb 15, 2005·Journal of Virology·Ron A M FouchierAlbert D M E Osterhaus
Aug 3, 2005·Nature Reviews. Microbiology·Taisuke Horimoto, Yoshihiro Kawaoka
Oct 18, 2005·Nature·Q Mai LeYoshihiro Kawaoka
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·M A Rameix-WeltiN Naffakh
Oct 18, 2007·Annual Review of Medicine·Anne Moscona
Feb 24, 2009·Nature Structural & Molecular Biology·Jianhua SuiWayne A Marasco
May 22, 2010·Bioorganic & Medicinal Chemistry Letters·Fei FengShin-Ichiro Nishimura
Jan 21, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ivan Fn HungKwok-Yung Yuen
Apr 10, 2012·Current Opinion in Virology·Damian C Ekiert, Ian A Wilson
Oct 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Peter S LeeIan A Wilson
Apr 13, 2013·The New England Journal of Medicine·Rongbao GaoYuelong Shu

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