PMID: 44666Nov 1, 1979

Antiviral effect of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4,5-diphenyl-oxyazolyl-(2)]hydrazone (IMET 98/69) in mice

Acta Virologica
A VeckenstedtI Béládi

Abstract

The potential in vivo antiviral activity of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4,5-diphenyl-oxazolyl-(2)]-hydrazone (IMET 98/69) was evaluated on model infections in mice. Animals treated subcutaneously (s.c.) with 1 mmole of the drug per kg body weight once daily for five days were significantly protected against a lethal infection with cardioviruses, Semliki forest virus and vaccinia virus. In influenza A and B virus models no antiviral activity was observed either after s.c. or oral treatment.

Related Concepts

3-(di-(2-hydroxyethyl)amino)acetophenone (4,5-diphenyloxazol-2-yl)hydrazone
Antiviral Agents
Arbovirus Infections
Medicinal Plants Testing, Preclinical
Encephalomyocarditis virus
Enterovirus Infections
Subcutaneous Injections
Orthomyxoviridae Infections
Munchnones
RNA Viruses

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