Antiviral effect of lithium chloride on infection of cells by canine parvovirus

Archives of Virology
Pei ZhouShoujun Li

Abstract

Canine parvovirus type 2 causes significant viral disease in dogs, with high morbidity, high infectivity, and high mortality. Lithium chloride is a potential antiviral drug for viruses. We determined the antiviral effect of Lithium Chloride on canine parvovirus type 2 in feline kidney cells. The viral DNA and proteins of canine parvovirus were suppressed in a dose-dependent manner by lithium chloride. Further investigation verified that viral entry into cells was inhibited in a dose-dependent manner by lithium chloride. These results indicated that lithium chloride could be a potential antiviral drug for curing dogs with canine parvovirus infection. The specific steps of canine parvovirus entry into cells that are affected by lithium chloride and its antiviral effect in vivo should be explored in future studies.

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Citations

Jul 6, 2016·BMC Veterinary Research·Zhanqin ZhaoYun Xue
May 22, 2020·International Journal of Bipolar Disorders·Andrea MurruUNKNOWN International Group for The Study of Lithium Treated Patients (IGSLi)

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Methods Mentioned

BETA
PCR

Software Mentioned

Prism
GraphPad Prism
GraphPad

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