Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus

Viruses
Xinghong ZhaoZhongqiong Yin

Abstract

Pseudorabies virus (PRV) is one of the most important pathogens of swine, resulting in devastating disease and economic losses worldwide. Nevertheless, there are currently no antiviral drugs available for PRV infection. Resveratrol (Res) was identified to exert its antiviral activity by inhibiting the PRV replication in preliminary investigations. In our previous study, we found that Res has anti-PRV activity in vitro. Here, we show that Res can effectively reduce the mortality and increase the growth performance of PRV-infected piglets. After Res treatment, the viral loads significantly (p < 0.001) decreased. Pathological symptoms, particularly inflammation in the brain caused by PRV infection, were significantly (p < 0.001) relieved by the effects of Res. In Res-treated groups, higher levels of cytokines in serum, including interferon gama, interleukin 12, tumor necrosis factor-alpha and interferon alpha were observed at 7 days post infection. These results indicated that Res possesses potent inhibitory activity against PRV-infection through inhibiting viral reproduction, alleviating PRV-induced inflammation and enhancing animal immunity, suggesting that Res is expected to be a new alternative control measure for PRV infection.

References

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Citations

May 16, 2020·International Journal of Clinical Practice·Mark A Marinella
Sep 13, 2018·Biomedicines·Bahare SalehiJavad Sharifi-Rad
Nov 15, 2019·Current Topics in Medicinal Chemistry·Sachin KumarHimangini Bansal
Mar 17, 2021·ACS Infectious Diseases·Ruicheng YangXiangru Wang
Mar 29, 2021·Journal of Veterinary Science·Chun Zhi RenTing Jun Hu
Jul 22, 2021·BMC Veterinary Research·Xiangchun RuanNuohao Jiang
Jul 20, 2021·BMC Veterinary Research·Lixia LiXu Song

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Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad Prism

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