Antiviral immune responses modulate the nature of central nervous system (CNS) disease in a murine model of multiple sclerosis

Immunological Reviews
K M DrescherM Rodriguez

Abstract

The spectrum of disease is influenced by factors related to both the pathogen and the host, as well as the end points used in defining disease. In this article, the issue of disease resistance versus susceptibility will be examined in the framework that genetic manipulation of either the pathogen or the host immune response alters the balance from disease protection towards pathogenesis. The response of the host may trigger both a protective and a pathogenic immune response. The failure to mount a protective immune response predisposes the pathogen to persistence, which then becomes the target for immunopathology. This review will examine the factors involved both in virus-mediated pathogenesis and in disease protection in the Theiler's model of human multiple sclerosis. By manipulating the character of the virus pathogen and the specificity of the immune response, the entire spectrum of human demyelinating disease is reproduced.

References

Apr 2, 1976·Science·H L Lipton, M C Dal Canto
Mar 1, 1977·Infection and Immunity·H L Lipton, C D Canto
Jul 1, 1979·Annals of Neurology·H L Lipton, M C Dal Canto
Jan 1, 1979·Annals of Neurology·J F Kurtzke, K Hyllested
Jan 1, 1992·Current Topics in Microbiology and Immunology·D S Schmid, B T Rouse
May 1, 1992·Journal of Virology·M LevyM Brahic
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J L FuR P Roos
Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Oct 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·M D JohnsonW O Whetsell
Jun 1, 1988·Journal of Neuroimmunology·E LaviS R Weiss
Jun 8, 1985·Lancet·W A SibleyK Clark
Mar 1, 1986·The Journal of Experimental Medicine·M RodriguezC S David
Jul 1, 1988·Neurology·M F Mendez, S Pogacar
Jul 1, 1985·Mayo Clinic Proceedings·M Rodriguez
Jun 1, 1982·Journal of Neuroimmunology·R P RoosB G Arnason
Aug 23, 1984·Nature·G H WongJ W Schrader
Sep 1, 1983·Archives of Neurology·J J Gilbert, M Sadler
Nov 1, 1995·Journal of Virology·M RodriguezR L Coffman

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Citations

Oct 3, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A GorisK Vandenbroeck
Jan 17, 2004·Clinical Microbiology Reviews·Emilia L OleszakChris D Platsoucas
May 24, 2000·Journal of Virology·A Azoulay-CaylaJ F Bureau
Mar 29, 2003·Journal of Virology·Chandran RamakrishnaStephen A Stohlman
Sep 13, 2005·Annual Review of Microbiology·Michel BrahicThomas Michiels
Jul 9, 2008·Journal of Neuroinflammation·Istvan PirkoAaron J Johnson
Nov 30, 2004·Virus Research·David FrancoBart Rombaut
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandran RamakrishnaCornelia C Bergmann
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N W MartenC C Bergmann
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·R J Fox, A M Rostami

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