journal cover

Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B

Gastroenterology

Oct 6, 2009

Paola FisicaroCarlo Ferrari

Abstract

The antiviral function of peripheral hepatitis B virus (HBV)-specific T cells can be increased in patients with chronic hepatitis B by blocking the interaction of programmed death (PD)-1 with its ligand PD-L1. However, no information is available about the effects of this blockade on in...read more

Mentioned in this Paper

Interleukins
Flow Cytometry
Biochemical Pathway
Hepatitis Be Antigen Measurement
T-Lymphocyte
Polymerase
IL7R gene
Leukocyte Differentiation Antigens, Human
Virus Diseases
Peripheral Blood
88
Paper Details
References
  • References23
  • Citations144
123
  • References23
  • Citations144
12345...

Similar Papers Found In These Feeds

Downstream Antiviral T Cell

Hepatitis B Virus

Hepatitis B virus is the most common cause of hepatitis worldwide and is associated with acute, fulminant, and chronic hepatitis, as well as liver cirrhosis and hepatocellular carcinoma. Here is the latest research.

Hbv Infection

Non-Small Cell Lung Cancer Recurrence

Acute Hepatitis C Virus Infection Clinical

Hepatitis D

Hepatitis D virus is a satellite virus whose life cycle is dependent on the presence of the hepatitis B. This can lead to a severe form of viral hepatitis in humans. Discover the latest research on Hepatitis D here.

T cell Differentiation

Differentiation of naive T cells into effector cells ensures optimal protection against pathogens and the development of immunological memory. Here is the latest research.

Cytokine Signaling & Transcription

Cytokines are proteins that are released by a subset of immune cells and play a role in intercellular communication, cell proliferation, differentiation, and survival. Discover the latest research on the influence of cytokine signaling on transcription here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Hepatitis C Virus Nonstructural Protein 5A

Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

Chronic Hepatitis C

T cells: Costimulatory Receptors

T cell activation requires engagement of both the T cell receptor and a co-stimulatory molecule. Lack of a co-stimulatory signal can result in T cell anergy, deletion, or immune tolerance. Find the latest research on T cell co-stimulatory receptors here.

Cross-Priming

Cross-priming is the process whereby professional APC, mainly dendritic cells, prime t-cells by presenting antigens processed from proteins of other cells such as tumor cells or virus-infected cells. Discover the latest research on cross-priming here.

Hepatitis C

Hepatitis C virus causes acute and chronic liver disease in humans, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Discover the latest research on Hepatitis C here.

Hepatitis C Virus Infection

Occult Hepatitis B Infection

Chronic Hepatitis B

Lymphocytic choriomeningitis

Lymphocytic choriomeningitis is caused by the Lymphocytic Choriomeningitis virus, a human zoonosis caused by a rodent-borne arenavirus, which been associated with both postnatal and intrauterine human diseases. Here is the latest research.

© 2020 Meta ULC. All rights reserved

Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B

Gastroenterology

Oct 6, 2009

Paola FisicaroCarlo Ferrari

PMID: 19800335

DOI: 10.1053/j.gastro.2009.09.052

Abstract

The antiviral function of peripheral hepatitis B virus (HBV)-specific T cells can be increased in patients with chronic hepatitis B by blocking the interaction of programmed death (PD)-1 with its ligand PD-L1. However, no information is available about the effects of this blockade on in...read more

Mentioned in this Paper

Interleukins
Flow Cytometry
Biochemical Pathway
Hepatitis Be Antigen Measurement
T-Lymphocyte
Polymerase
IL7R gene
Leukocyte Differentiation Antigens, Human
Virus Diseases
Peripheral Blood
88

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References23
  • Citations144
123
  • References23
  • Citations144
12345...
/papers/antiviral-intrahepatic-t-cell-responses-can-be/19800335