PMID: 8938570Nov 1, 1996Paper

Antiviral nonspecific immunity of human placenta at term: possible role of endogenous tumor necrosis factors and interferons

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
E ParadowskaW Jarosz

Abstract

The antiviral immunity of human placenta and amniotic membrane in an organ culture (OC) system was studied. Freshly isolated explants of most of the placentas at term and the amniotic membranes were found to be relatively resistant to herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV), and vesicular stomatitis virus (VSV) infections. After in vitro aging, however, the OC acquired the sensitivity to the viruses. In about 66%-90% of placentas, resistance of freshly isolated explants to the infection was observed. This indicates that the placentas displayed a constitutive immunity against the viruses. To study the role of endogenous cytokines in antiviral immunity, we added specific antibodies neutralizing IFN and TNF activities to VSV-infected OC and checked their influence on viral replication. Increases of 10-fold to 100-fold of VSV replication in the OC treated with anti-TNF-alpha, anti-IFN-alpha, anti-IFN-gamma or anti-IFN-beta sera were observed. The results indicate the importance of the endogenous cytokines in placental and amniotic membrane immunity. However, we did not observe a simple correlation between the spontaneous IFN and TNF production and the level of resistance against viruses. In view of th...Continue Reading

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Citations

Nov 4, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E ParadowskaZ J Leśnikowski
Jul 16, 2010·Journal of Periodontology·Ines VelezMaria Hernandez
Oct 11, 2011·Experimental Gerontology·Bogna JatczakZofia Błach-Olszewska
Jul 30, 2008·Journal of the Neurological Sciences·Marta SochockaZofia Błach-Olszewska
Nov 3, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Edyta ParadowskaZbigniew J Leśnikowski
Jan 23, 2008·Journal of Clinical Gastroenterology·Delia Maria PaternosterAnnarosa Floreani
Jul 11, 2019·Biological Research for Nursing·Madeleine Parent-VachonPascal Vachon

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