Antiviral prophylaxis for cytomegalovirus infection in allogeneic hematopoietic cell transplantation

Blood Advances
Kaiwen ChenFrancisco M Marty

Abstract

Patients treated with allogeneic hematopoietic cell transplantation (HCT) are at risk of cytomegalovirus (CMV) reactivation and disease, which results in increased morbidity and mortality. Although universal antiviral prophylaxis against CMV improves outcomes in solid organ transplant recipients, data have been conflicting regarding such prophylaxis in patients undergoing allogeneic HCT. We conducted a systematic review of randomized trials of prophylactic antivirals against CMV after allogeneic HCT to summarize the evolution of the field over the last 35 years and evaluate the prophylactic potential of antiviral agents against CMV after allogeneic HCT. Electronic databases were queried from database inception through 31 December 2017. For included studies, incidence of CMV infection and all-cause mortality were collected as primary outcomes; CMV disease incidence, use of preemptive therapy, and drug toxicities were collected as secondary outcomes. Nineteen clinical trials conducted between 1981 and 2017 involving a total of 4173 patients were included for review. Prophylactic strategies included use of acyclovir, valacyclovir, ganciclovir, maribavir, brincidofovir, and letermovir compared with placebo or a comparator antiviral...Continue Reading

References

Apr 11, 1991·The New England Journal of Medicine·R H Rubin
Jul 9, 1981·The New England Journal of Medicine·R SaralP S Lietman
Feb 1, 1993·Annals of Internal Medicine·J M GoodrichJ D Meyers
Dec 1, 1996·The Journal of General Virology·M MendelsonJ Sinclair
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·J ReefschlaegerH Ruebsamen-Waigmann
Apr 4, 2002·Blood·Per LjungmanUNKNOWN Valacyclovir International Bone Marrow Transplant Study Group
Mar 11, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Drew J WinstonUNKNOWN Valacyclovir Cytomegalovirus Study Group
Sep 25, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael BoeckhJohn Zaia
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
Dec 20, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Francisco M Marty, Robert H Rubin
Jun 9, 2006·The Journal of General Virology·John Sinclair, Patrick Sissons
Jan 6, 2010·Antimicrobial Agents and Chemotherapy·Peter LischkaHolger Zimmermann
Apr 30, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheri Lewis BateMichael J Cannon
Jun 4, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rune AmundsenAnders Asberg
Feb 8, 2011·Drug Metabolism and Pharmacokinetics·Yoshihisa Shitara
Mar 24, 2012·Current Opinion in Virology·Francisco M Marty, Michael Boeckh
Sep 27, 2013·The New England Journal of Medicine·Francisco M MartyUNKNOWN CMX001-201 Clinical Study Group
May 9, 2014·The New England Journal of Medicine·Roy F ChemalyUNKNOWN AIC246 Study Team
Jun 2, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Guenther KoehneRichard J O'Reilly

❮ Previous
Next ❯

Citations

Sep 25, 2018·Expert Review of Vaccines·Don Jeffrey DiamondJohn A Zaia
Dec 14, 2018·Current Opinion in Infectious Diseases·Sanjeet S Dadwal
Mar 23, 2019·International Journal of Molecular Sciences·Caroline MangareBritta Eiz-Vesper
Jul 31, 2019·Journal of the Pediatric Infectious Diseases Society·Jacob T KilgoreYeh-Chung Chang
Mar 7, 2020·The Journal of Infectious Diseases·Ghady HaidarNina Singh
Apr 26, 2019·International Journal of Molecular Sciences·Joana R LériasMarkus Maeurer
Dec 14, 2018·International Journal of Molecular Sciences·Michael M McVoyLawrence M Kauvar
May 30, 2019·The Journal of Antimicrobial Chemotherapy·Volker StrengerMartin Benesch
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Michele MalagolaDomenico Russo
Sep 20, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O Beyar-KatzM Paul
Oct 31, 2020·Frontiers in Pediatrics·Ashish O Gupta, John E Wagner
Oct 1, 2020·Expert Review of Hematology·Andrea BacigalupoLivio Pagano
Dec 21, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yu AkahoshiHideki Nakasone
Apr 19, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Kaiwen ChenFrancisco M Marty
May 13, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Stephanie LamDuncan Purtill
Jul 27, 2021·Current Treatment Options in Infectious Diseases·Niyati JakhariaDavid J Riedel
Aug 14, 2021·Frontiers in Pediatrics·Asmaa FerdjallahMargaret L MacMillan
Nov 18, 2021·Blood Advances·Yu AkahoshiHideki Nakasone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.