Antiviral RNA interference in mammals

Current Opinion in Immunology
Shou-Wei DingWan-Xiang Li

Abstract

Infection of plants and insects with RNA and DNA viruses triggers Dicer-dependent production of virus-derived small interfering RNAs (vsiRNAs), which subsequently guide specific virus clearance by RNA interference (RNAi). Consistent with a major antiviral function of RNAi, productive virus infection in these eukaryotic hosts depends on the expression of virus-encoded suppressors of RNAi (VSRs). The eukaryotic RNAi pathway is highly conserved, particularly between insects and mammals. This review will discuss key recent findings that indicate a natural antiviral function of the RNAi pathway in mammalian cells. We will summarize the properties of the characterized mammalian vsiRNAs and VSRs and highlight important questions remaining to be addressed on the function and mechanism of mammalian antiviral RNAi.

Citations

Oct 12, 2018·Nature Reviews. Immunology·Zhongxin GuoShou-Wei Ding
Aug 20, 2019·Cellular Microbiology·Urbi MukhopadhyayMamta Chawla-Sarkar
Feb 23, 2020·International Journal of Molecular Sciences·Tomoko Takahashi, Kumiko Ui-Tei
Jul 16, 2020·The Journal of General Virology·Jingfang MuXi Zhou
Sep 26, 2019·Scientific Reports·Susan SchusterRonald P van Rij
Dec 14, 2018·PLoS Pathogens·Zicong XieHongsheng Ouyang
Aug 6, 2020·MBio·Qingxia HanShou-Wei Ding
Apr 10, 2019·Wiley Interdisciplinary Reviews. RNA·Sarah ResselAmy H Buck
Oct 4, 2020·International Journal of Molecular Sciences·Eleni I TheotokiEma Anastasiadou
Dec 9, 2020·Pathogens·Klaudia WieczorekElzbieta Kierzek
Feb 16, 2021·Briefings in Bioinformatics·Qingren MengYu Kang
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Jianxiong ZengZhen Zhao
May 16, 2021·Immunity & Ageing : I & a·Daniel K FabianJanet M Thornton
Jun 14, 2021·Photodiagnosis and Photodynamic Therapy·Valentina RapozziRebeka Strgar
Jul 11, 2021·Science·Shabihah Shahrudin, Shou-Wei Ding
Oct 31, 2021·BMC Research Notes·Seyyed Reza MousaviHajie Lotfi
Mar 13, 2020·Molecular Therapy. Nucleic Acids·Hao LiZhihua Kou

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