PMID: 1696959Jun 1, 1990

Antiviral strategies in chronic hepatitis B virus infection: II. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds

Journal of Medical Virology
G CiviticoS Locarnini

Abstract

Primary duck hepatocyte (PDH) cultures, congenitally infected with the duck hepatitis B virus (DHBV), were grown on feeder cell layers of irradiated human embryonic lung fibroblasts and then exposed to a number of compounds with recognized or potential antiviral activity. These compounds included conventional antiviral agents, reverse transcriptase inhibitors, compounds with activity to supercoiled-DNA, and DNA-binding agents. Twenty-three compounds were evaluated, and 13 were found to inhibit significantly viral DNA replication. Seven of these compounds (ellipticine, amsacrine, coumermycin A1, Adriamycin, mitozantrone, chloroquine, and neocarzinostatin) acted at the level of viral SC DNA and significantly inhibited production of duck hepatitis B surface antigen (DHBsAg). Conventional agents that inhibited DHBV DNA replication included ganciclovir, acyclovir, bromovinyldeoxyuridine, ribavirin, phosphonoformate, and dideoxyadenosine. Except for dideoxyadenosine, these inhibitors of viral DNA synthesis did not significantly inhibit DHBsAg production. Two additional compounds, novobiocin and nalidixic acid, altered the pattern of viral DNA replication, especially the generation and processing of viral SC DNA, and also inhibited th...Continue Reading

References

Feb 16, 1978·Nature·S Z Hirschman, E Garfinkel
Feb 1, 1986·Seminars in Liver Disease·H C ThomasM Pignatelli
Aug 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I FourelC Trépo
Mar 5, 1988·Lancet·R J Epstein
Mar 1, 1987·The Journal of General Virology·Y NishiyamaK Shimokata
Jan 1, 1986·Intervirology·I GustA J Zuckerman
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HirotaK Okuda
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O YokosukaJ Summers
Oct 1, 1983·The Journal of General Virology·Y SumiyoshiK Kano
Aug 1, 1984·The Journal of Antimicrobial Chemotherapy·O E VarnierG C Schito
May 1, 1983·The Journal of Antimicrobial Chemotherapy·M F Parry
Dec 1, 1983·Virology·W S MasonJ Summers

Citations

Jun 1, 1994·Journal of Medical Virology·K IjichiK Shimada
Feb 6, 1999·Journal of Biomedical Science·P PantazisJ Wyche
Jul 11, 1998·Molecular Biotechnology·W B OffenspergerH E Blum
Sep 12, 2000·Current Gastroenterology Reports·F Yao, R G Gish
Jan 1, 1996·European Journal of Medicinal Chemistry·G PèpeJ Kraus
Jul 19, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G Di StefanoL Fiume
Dec 22, 1999·Journal of Viral Hepatitis·T Shaw, S Locarnini
Jan 1, 1991·Journal of Gastroenterology and Hepatology·S Locarnini
Nov 1, 1991·Antimicrobial Agents and Chemotherapy·W B OffenspergerW Gerok
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·T ShawS Locarnini
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·D ColledgeT Shaw
Jul 17, 2007·International Journal of Antimicrobial Agents·Jean-Marc RolainDidier Raoult
Apr 30, 2014·Microbiology and Immunology·Kleber Juvenal Silva FariasBenedito Antônio Lopes da Fonseca
Jul 1, 1996·Baillière's Clinical Gastroenterology·G M Dusheiko
Dec 1, 1990·Journal of Medical Virology·J Z NiuS Locarnini
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J S McMillanS Locarnini
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W B OffenspergerD Häussinger

Related Concepts

Antiviral Agents
Genotoxic Stress
DNA Replication
DNA Helix Destabilizing Proteins
DNA, Superhelical
DNA, Viral
Ducks
Hepatitis, Viral, Animal
Intercalating Agents
Liver

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