Antiviral susceptibility of Herpes simplex viruses and its clinical correlates: a single center's experience

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
N RabellaG Prats

Abstract

The in vitro susceptibility to acyclovir of 204 herpes simplex virus isolates from 165 immunocompromised patients treated at our hospital was determined by the cytopathic effect reduction assay. Approximately 95% of herpes simplex virus 1 and 73% of herpes simplex virus 2 isolates were inhibited by acyclovir at concentrations of <2 microgram/mL. From 8 patients (5%), an isolate with low susceptibility to acyclovir (50% inhibitory dose, >3 microgram/mL) was recovered. Medical records of 83 patients were reviewed. Lesions resolved in most of the patients, independent of treatment. Treatment failures were not always associated with isolation of an in vitro-resistant virus. On the contrary, when a virus with low susceptibility to acyclovir was isolated, resolution of the lesion was the rule. In 9 of 10 patients with subsequent recurrent episodes of disease, the susceptibility of the viruses isolated was similar to that of the first episode. Routine susceptibility testing in our geographic area is not encouraged because of the low incidence of acyclovir-resistant herpes simplex viruses.

References

May 1, 1979·Antimicrobial Agents and Chemotherapy·C S CrumpackerM J Levin
Aug 1, 1992·Antimicrobial Agents and Chemotherapy·P A Chatis, C S Crumpacker
Apr 1, 1992·Clinical Microbiology Reviews·B Bean
Mar 15, 1990·Annals of Internal Medicine·J A EnglundH H Balfour
Feb 2, 1989·The New England Journal of Medicine·K S ErlichC S Crumpacker
Oct 1, 1986·The Journal of Antimicrobial Chemotherapy·D W BarryM N Ellis
May 1, 1980·The Journal of Infectious Diseases·E De ClercqD Shugar
Apr 1, 1982·Antimicrobial Agents and Chemotherapy·E De Clercq
Jul 20, 1982·The American Journal of Medicine·C McLarenD W Barry
Sep 1, 1983·The Journal of Antimicrobial Chemotherapy·C DekkerD W Barry
Sep 1, 1983·The Journal of Antimicrobial Chemotherapy·P Collins
Nov 1, 1983·The Journal of Infectious Diseases·C McLarenD W Barry
Aug 1, 1984·The Journal of Antimicrobial Chemotherapy·B Oberg, N G Johansson
Jan 1, 1993·Journal of Medical Virology·P Collins, M N Ellis
Mar 1, 1996·The Journal of Antimicrobial Chemotherapy·D W Kimberlin, R J Whitley
Mar 1, 1959·Proceedings of the National Academy of Sciences of the United States of America·M Ho, J F Enders

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Citations

Jun 18, 2014·Anais Brasileiros De Dermatologia·Carlos NozawaRosa Elisa Carvalho Linhares

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