Antiviral therapy for treatment naïve patients with hepatitis C virus

Infectious Disease Clinics of North America
Sangik Oh, Nezam H Afdhal

Abstract

This article focuses on the most recent therapies for patients with hepatitis C virus (HCV) who are naive to therapy. The primary end point for the treatment of naive HCV patients is viral eradication or a sustained virological response, which is defined as the absence of HCV in the serum, as detected by a sensitive polymerase chain reaction test, 24 weeks after stopping antiviral therapy. Recent data suggest that an SVR can be equated with a biochemical,virological, and histological response that is sustained for up to 5 years and is conceptually a cure of HCV in 90% of patients.

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Citations

Jul 7, 2007·Archives of Medical Research·Solange Heller, Pedro Valencia-Mayoral
Dec 6, 2007·Alimentary Pharmacology & Therapeutics·F Poordad
May 23, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Rosângela TeixeiraScott L Friedman
May 3, 2006·PLoS Pathogens·Christian GrantSteven Jacobson
Apr 25, 2008·Journal of Hepatology·Nezam AfdhalRafael Esteban
Aug 6, 2008·European Journal of Gastroenterology & Hepatology·Soraya de Mattos Camargo GrossmannMaria Auxiliadora Vieira do Carmo

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