Abstract
This article focuses on the most recent therapies for patients with hepatitis C virus (HCV) who are naive to therapy. The primary end point for the treatment of naive HCV patients is viral eradication or a sustained virological response, which is defined as the absence of HCV in the serum, as detected by a sensitive polymerase chain reaction test, 24 weeks after stopping antiviral therapy. Recent data suggest that an SVR can be equated with a biochemical,virological, and histological response that is sustained for up to 5 years and is conceptually a cure of HCV in 90% of patients.
References
Dec 15, 1995·Annals of Internal Medicine·A M Di BisceglieJ H Hoofnagle
Nov 1, 1996·Journal of Hepatology·G DusheikoO Weiland
Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C BodenheimerL B Seeff
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J Alter
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MarcellinS Erlinger
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SangiovanniG Minoli
Nov 10, 1998·Lancet·T PoynardJ Albrecht
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L Bonkovsky, J M Woolley
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Dec 7, 2000·The New England Journal of Medicine·S ZeuzemM J Brunda
Dec 7, 2000·The New England Journal of Medicine·E J HeathcoteJ De Pamphilis
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K L LindsayUNKNOWN Hepatitis Interventional Therapy Group
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Feb 14, 2003·Gut·U SiebertUNKNOWN International Hepatitis Interventional Therapy (IHIT) Group
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary L DavisJanice Albrecht
Citations
May 16, 2007·Expert Opinion on Investigational Drugs·Martin Braddock
Jul 7, 2007·Archives of Medical Research·Solange Heller, Pedro Valencia-Mayoral
Dec 6, 2007·Alimentary Pharmacology & Therapeutics·F Poordad
May 23, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Rosângela TeixeiraScott L Friedman
May 3, 2006·PLoS Pathogens·Christian GrantSteven Jacobson
Apr 25, 2008·Journal of Hepatology·Nezam AfdhalRafael Esteban
Aug 6, 2008·European Journal of Gastroenterology & Hepatology·Soraya de Mattos Camargo GrossmannMaria Auxiliadora Vieira do Carmo