Antiviral treatment of chronic hepatitis B virus infection. I. Changes in viral markers with interferon combined with adenine arabinoside

The Journal of Infectious Diseases
G H ScullardT C Merigan

Abstract

Twenty patients with chronic active hepatitis and 12 patients with chronic persistent hepatitis associated with hepatitis B virus (HBV) infection were treated with human leukocyte interferon or adenine arabinoside alone or in combination. With interferon alone, four of 16 patients showed a permanent disappearance of HBV-associated DNA polymerase (DNAP) activity from serum. Of six patients treated with adenine arabinoside alone, only one patient became permanently DNAP-negative. With a regimen of multiple cycles of combined interferon and adenine arabinoside, seven of 16 male patients became permanently DNAP-negative. Of 69 patients who met the criteria for admission to the program, spontaneous decreases in DNAP activity without treatment were observed in only 9% during a mean observation period of 10 months. In general, patients with chronic active hepatitis, those who are female, and those with a history of recent steroid therapy responded to the antiviral agents significantly better than did the other patients.

Citations

Apr 1, 1993·Digestive Diseases and Sciences·R P Perrillo
Jan 1, 1986·Digestive Diseases and Sciences·J Y WangB N Chiang
Aug 1, 1984·European Journal of Clinical Microbiology·P G Higgins
May 11, 1995·Biochemical Pharmacology·T E Kitos, D L Tyrrell
Dec 1, 1985·Antiviral Research·D S Freestone
Nov 15, 1988·Biochemical and Biophysical Research Communications·S SuzukiD L Tyrrell
Aug 2, 2000·Journal of Gastroenterology and Hepatology·R Guan
Nov 15, 1984·The New England Journal of Medicine·T C Merigan
Dec 18, 1986·The New England Journal of Medicine·J H HoofnagleE A Jones
Dec 21, 1995·The New England Journal of Medicine·T C Merigan
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D ShouvalD A Shafritz
Aug 1, 1991·Journal of Interferon Research·M OnjiY Ohta
Jan 1, 1986·Antimicrobial Agents and Chemotherapy·M EisenbergT C Merigan
Apr 5, 1986·British Medical Journal·G Alexander, R Williams
Jun 1, 1989·Genitourinary Medicine·K Gelmon, I V Weller
Jan 1, 1982·The Journal of Clinical Investigation·S L SacksI H Fox
Oct 26, 1999·Critical Reviews in Oncology/hematology·G K LauR Liang
Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P Y WongR Williams
Jun 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R M BeattieS P Rigden
Jan 1, 1989·Baillière's Clinical Gastroenterology·G Alexander
Sep 1, 1990·Baillière's Clinical Gastroenterology·J L BrownH C Thomas
Nov 11, 1989·Lancet
Aug 1, 1993·Journal of Internal Medicine·A GruberM Björkholm

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